68 Ga-DOTA-FAPI-46 PET/CT Imaging for Restaging in a Patient With Metastatic Pheochromocytoma : Comparison With 68 Ga-DOTA-TATE PET/CT

Pheochromocytomas (PHEOs) are neural crest-derived tumors originating from the chromaffin cells of the adrenal medulla and were recognized as one of the subtypes of paragangliomas by the World Health Organization in 2022. 68 Ga-labeled somatostatin analog ( 68 Ga-DOTA-NOC, 68 Ga-DOTA-TOC, and 68 Ga-...

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Bibliographic Details
Published in:Clinical nuclear medicine 2024-11, Vol.49 (11), p.e622
Main Authors: Şahin, Rahime, Baloğlu, Mehmet Can, Ergül, Nurhan, Çermik, Tevfik Fikret, Arslan, Esra
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - diagnostic imaging
Adrenal Gland Neoplasms - pathology
Adrenal Gland Neoplasms - secondary
Adult
Humans
Male
Neoplasm Metastasis
Neoplasm Staging
Octreotide - analogs & derivatives
Organometallic Compounds
Pheochromocytoma - diagnostic imaging
Pheochromocytoma - pathology
Positron Emission Tomography Computed Tomography
Quinolines
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Summary:Pheochromocytomas (PHEOs) are neural crest-derived tumors originating from the chromaffin cells of the adrenal medulla and were recognized as one of the subtypes of paragangliomas by the World Health Organization in 2022. 68 Ga-labeled somatostatin analog ( 68 Ga-DOTA-NOC, 68 Ga-DOTA-TOC, and 68 Ga-DOTA-TATE) PET imaging has shown significant performance compared with 123 MIBG scintigraphy in the diagnosis of paragangliomas. It is now known that fibroblast activation protein (FAP) is overexpressed by various cancer-associated fibroblasts, including PHEOs. We would like to present the findings of 68 Ga-DOTA-FAPI-46 PET/CT and 68 Ga-DOTA-TATE PET/CT imaging performed for restaging on a 42-year-old man diagnosed with metastatic PHEO.
ISSN:1536-0229
1536-0229
DOI:10.1097/RLU.0000000000005481