Evaluation the efficacy of microneedling with topical metformin solution compared with microneedling with topical vitamin C solution in treatment of melasma

Several treatment modalities have been used for the treatment of melasma. Topical metformin is an anti-diabetic drug, which has melanopenic action. Vitamin C acts on melanin by inhibiting the tyrosinase enzyme, thus inhibiting melanogenesis. To compare the efficacy and safety of microneedling combin...

Full description

Saved in:
Bibliographic Details
Published in:Archives of dermatological research 2024-10, Vol.316 (9), p.662, Article 662
Main Authors: Mahmoud, Manal Mahmoud Yosef, Kamel, Abeer Moustafa, Galal, Sara Ahmed
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Administration, Topical
Adult
Antidiabetics
Ascorbic acid
Ascorbic Acid - administration & dosage
Combined Modality Therapy
Dermatology
Diabetes mellitus
Dry Needling - methods
Female
Humans
Medicine
Medicine & Public Health
Melanin
Melanosis - diagnosis
Melanosis - drug therapy
Melanosis - therapy
Metformin
Metformin - administration & dosage
Metformin - therapeutic use
Middle Aged
Needles
Original Paper
Percutaneous Collagen Induction
Treatment Outcome
Vitamin C
Young Adult
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several treatment modalities have been used for the treatment of melasma. Topical metformin is an anti-diabetic drug, which has melanopenic action. Vitamin C acts on melanin by inhibiting the tyrosinase enzyme, thus inhibiting melanogenesis. To compare the efficacy and safety of microneedling combined with topical metformin solution versus microneedling combined with topical vitamin C in the treatment of melasma. A spitted-face interventional comparative on 30 female patients suffering from melasma. The right side of the face was treated with microneedling and topical metformin, while the left side was treated with microneedling and topical vitamin C solution. Hemi-MASI score decreased significantly after treatment from before treatment in both groups P-value 
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-024-03355-9