A Biobehavioral Perspective on Caring for Allogeneic Hematopoietic Stem Cell Transplant Survivors with Graft-Versus-Host Disease

Among the potential complications of allogeneic hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD) is common and associated with significant physical and psychosocial symptom burden. Despite substantial advances in GVHD treatment, the global immune suppression that freq...

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Bibliographic Details
Published in:Transplantation and cellular therapy 2024-09, Vol.30 (9), p.S493-S512
Main Authors: Lahijani, Sheila, Rueda-Lara, Maria, McAndrew, Natalie, Nelson, Ashley M., Guo, Michelle, Knight, Jennifer M., Wiener, Lori, Miran, Damien M., Gray, Tamryn F., Keane, Emma P., Yek, Ming Hwei, Sannes, Timothy S., Applebaum, Allison J., Fank, Patricia, Babu, Pallavi, Pozo-Kaderman, Cristina, Amonoo, Hermioni L.
Format: Article
Language:English
Subjects:
Adult
Biobehavioral
Functioning
Graft vs Host Disease - psychology
Graft-versus-host disease
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - psychology
Humans
Pediatrics
Psychological well-being
Psychosocial
Quality of life
Survivors - psychology
Transplantation, Homologous
Well-being
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Summary:Among the potential complications of allogeneic hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD) is common and associated with significant physical and psychosocial symptom burden. Despite substantial advances in GVHD treatment, the global immune suppression that frequently accompanies GVHD treatment also contributes to high rates of physical and emotional suffering and mortality. The complex manifestations of GVHD and its treatment warrant a multidisciplinary team-based approach to managing patients' multi-organ system comorbidities. A biobehavioral framework can enhance our understanding of the complex association between medications, physical symptoms, and psychosocial distress in patients with GVHD. Hence, for this perspective, we highlight the importance of addressing both the physical and psychosocial needs experienced by patients with GVHD and provide guidance on how to approach and manage those symptoms and concerns as part of comprehensive cancer care.
ISSN:2666-6367
2666-6367
DOI:10.1016/j.jtct.2024.05.024