Cutaneous Chronic Graft-Versus-Host Disease: Clinical Manifestations, Diagnosis, Management, and Supportive Care

Cutaneous chronic graft-versus-host disease (cGVHD) is associated with morbidity, mortality, and impaired quality of life after hematopoietic stem cell transplantation. The clinical features of cutaneous cGVHD are heterogeneous but can be broadly classified into nonsclerotic or sclerotic presentatio...

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Bibliographic Details
Published in:Transplantation and cellular therapy 2024-09, Vol.30 (9), p.S513-S533
Main Authors: Shi, Connie R., Ferreira, Alana L., Kaur, Manjit, Xiang, David, Caputo, Jean, Choe, Hannah K., Hamad, Nada, Cowen, Edward W., Kaffenberger, Benjamin H., Baumrin, Emily
Format: Article
Language:English
Subjects:
Chronic Disease
Cutaneous graft versus host disease
Diagnosis, Differential
Graft vs Host Disease - diagnosis
Graft vs Host Disease - etiology
Graft vs Host Disease - therapy
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Quality of Life
Skin Diseases - diagnosis
Skin Diseases - etiology
Skin Diseases - therapy
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Description
Summary:Cutaneous chronic graft-versus-host disease (cGVHD) is associated with morbidity, mortality, and impaired quality of life after hematopoietic stem cell transplantation. The clinical features of cutaneous cGVHD are heterogeneous but can be broadly classified into nonsclerotic or sclerotic presentations. This review provides an overview of clinical presentation, diagnosis and differential diagnosis, grading, and treatment of cutaneous cGVHD. Particular attention is given to cutaneous cGVHD in skin of color, which can have unique features and is generally underrepresented in the literature leading to delays in diagnosis. Finally, an overview of long-term skin care for patients with cutaneous cGVHD is provided in order to support patients from a dermatologic perspective as they recover from cGVHD. Multidisciplinary care with frequent communication between transplant specialists and dermatologists is critical to effectively managing cutaneous cGVHD.
ISSN:2666-6367
2666-6367
DOI:10.1016/j.jtct.2024.05.020