Circulating miR-133a-3p and miR-451a as potential biomarkers for diagnosis of coronary artery disease

Coronary artery disease (CAD) remains the leading cause of mortality and morbidity around the world. Despite significant progress in the diagnosis and treatment of cardiovascular diseases, still there is a clinical need to identify novel biomarkers for early diagnosis and treatment of CAD. The aim o...

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Published in:Acta Cardiologica 2024-09, Vol.79 (7), p.813-823
Main Authors: Andiappan, Rathinavel, Govindan, Ramajayam, Ramasamy, Thirunavukkarasu, Poomarimuthu, Maheshkumar
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Case-Control Studies
Circulating MicroRNA - blood
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - genetics
Female
Humans
Male
MicroRNAs - blood
Middle Aged
Real-Time Polymerase Chain Reaction
ROC Curve
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Summary:Coronary artery disease (CAD) remains the leading cause of mortality and morbidity around the world. Despite significant progress in the diagnosis and treatment of cardiovascular diseases, still there is a clinical need to identify novel biomarkers for early diagnosis and treatment of CAD. The aim of the study is to investigate circulating miRNAs in CAD patients to identify potential biomarkers for early detection and therapeutic management of CAD. We assessed the expression of different candidate miRNAs (miR-21-5p, miR-133a-3p, miR-221-3p, miR-451a and miR-584-5p) in plasma from 50 CAD patients and 50 controls by qRT-PCR analysis. The expression levels of miR-133a-3p (fold change (FC): 28.05,  
ISSN:0001-5385
1784-973X
1784-973X
0373-7934
DOI:10.1080/00015385.2024.2410599