Loading…

Areas of uncertainty on the diagnosis, treatment, and follow-up of hypophosphatemia in adults: an Italian Delphi consensus

The study aimed to present the results of a Delphi consensus involving Italian experts focusing on the management of hypophosphatemia in adults. A multidisciplinary advisory board of nine physicians, experts in hypophosphatemia management, was established. Next, a literature search was performed to...

Full description

Saved in:
Bibliographic Details
Published in:Journal of endocrinological investigation 2024-10
Main Authors: Chiodini, Iacopo, d'Angela, Daniela, Falchetti, Alberto, Gennari, Luigi, Malavolta, Nazzarena, Masi, Laura, Migliore, Antonio, Orso, Massimiliano, Polistena, Barbara, Rendina, Domenico, Scillitani, Alfredo, Spandonaro, Federico, Vezzoli, Giuseppe, Vescini, Fabio
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c228t-393989abc9707e9a05a0a105eba64d52fbf9ea635a08a4279e359bf16d420e1d3
container_end_page
container_issue
container_start_page
container_title Journal of endocrinological investigation
container_volume
creator Chiodini, Iacopo
d'Angela, Daniela
Falchetti, Alberto
Gennari, Luigi
Malavolta, Nazzarena
Masi, Laura
Migliore, Antonio
Orso, Massimiliano
Polistena, Barbara
Rendina, Domenico
Scillitani, Alfredo
Spandonaro, Federico
Vezzoli, Giuseppe
Vescini, Fabio
description The study aimed to present the results of a Delphi consensus involving Italian experts focusing on the management of hypophosphatemia in adults. A multidisciplinary advisory board of nine physicians, experts in hypophosphatemia management, was established. Next, a literature search was performed to identify international guidelines, consensus, and clinical pathways, which were later presented to the advisory board. Collaboratively, the advisory board and authoring team selected key statements for the consensus process and focused on areas of uncertainty related to the management of hypophosphatemia. The advisory board also indicated the experts to be invited to participate in the consensus process. The Delphi method was employed to reach a consensus. The literature search yielded one guideline, five consensus documents, and one clinical pathway. While our search strategy aimed to identify documents on the management of all types of hypophosphatemia, most of the guidelines and consensus documents retrieved focused on X-linked hypophosphatemia. The consensus process focused on 11 key issues, achieving strong convergence (over 70% consensus) in the first Delphi round for 8 out of the 11 statements. Three statements proceeded to the second round, with strong agreement reached for two. Notably, consensus was not reached for the statement concerning the measurement of fibroblast growth factor 23 for diagnostic purposes. The study revealed that the community of clinical experts is well-informed and in agreement regarding hypophosphatemia management. It emphasized the importance of developing clear national guidance documents to support clinicians and multidisciplinary teams in patient management. These documents are crucial not only for healthcare professionals but also for those responsible for defining pathways and services, facilitating a more accurate management of hypophosphatemic patients.
doi_str_mv 10.1007/s40618-024-02458-4
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3114152053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3114152053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-393989abc9707e9a05a0a105eba64d52fbf9ea635a08a4279e359bf16d420e1d3</originalsourceid><addsrcrecordid>eNpNkEtr3TAQhUVoyfsPZBG0zCJO9LAtq7uQNg8IdNOsxdgexwq25Hhkwu2vr29vGroYzjCccxg-xs6kuJJCmGvKRSmrTKh8O0WV5XvsUBolskpX5Zf_9gN2RPQqhDa6MvvsQFttjBX6kP2-mRGIx44vocE5gQ9pw2PgqUfeengJkTxd8rTa0oghXXIILe_iMMT3bJm2yX4zxamPNPWQcPTAfeDQLkOib6uZPyYY_KrfcZh6z5sYCAMtdMK-djAQnn7oMXu--_Hr9iF7-nn_eHvzlDVKVSlbf7WVhbqxRhi0IAoQIEWBNZR5W6iu7ixCqddzBbkyFnVh606Wba4EylYfs4td7zTHtwUpudFTg8MAAeNCTkuZy0KJQq9WtbM2cySasXPT7EeYN04Kt2Xudszdytv9Ze7yNXT-0b_UI7afkX-Q9R-iXX4v</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3114152053</pqid></control><display><type>article</type><title>Areas of uncertainty on the diagnosis, treatment, and follow-up of hypophosphatemia in adults: an Italian Delphi consensus</title><source>Springer Link</source><creator>Chiodini, Iacopo ; d'Angela, Daniela ; Falchetti, Alberto ; Gennari, Luigi ; Malavolta, Nazzarena ; Masi, Laura ; Migliore, Antonio ; Orso, Massimiliano ; Polistena, Barbara ; Rendina, Domenico ; Scillitani, Alfredo ; Spandonaro, Federico ; Vezzoli, Giuseppe ; Vescini, Fabio</creator><creatorcontrib>Chiodini, Iacopo ; d'Angela, Daniela ; Falchetti, Alberto ; Gennari, Luigi ; Malavolta, Nazzarena ; Masi, Laura ; Migliore, Antonio ; Orso, Massimiliano ; Polistena, Barbara ; Rendina, Domenico ; Scillitani, Alfredo ; Spandonaro, Federico ; Vezzoli, Giuseppe ; Vescini, Fabio ; Delphi Panel Members ; Delphi Panel Members</creatorcontrib><description>The study aimed to present the results of a Delphi consensus involving Italian experts focusing on the management of hypophosphatemia in adults. A multidisciplinary advisory board of nine physicians, experts in hypophosphatemia management, was established. Next, a literature search was performed to identify international guidelines, consensus, and clinical pathways, which were later presented to the advisory board. Collaboratively, the advisory board and authoring team selected key statements for the consensus process and focused on areas of uncertainty related to the management of hypophosphatemia. The advisory board also indicated the experts to be invited to participate in the consensus process. The Delphi method was employed to reach a consensus. The literature search yielded one guideline, five consensus documents, and one clinical pathway. While our search strategy aimed to identify documents on the management of all types of hypophosphatemia, most of the guidelines and consensus documents retrieved focused on X-linked hypophosphatemia. The consensus process focused on 11 key issues, achieving strong convergence (over 70% consensus) in the first Delphi round for 8 out of the 11 statements. Three statements proceeded to the second round, with strong agreement reached for two. Notably, consensus was not reached for the statement concerning the measurement of fibroblast growth factor 23 for diagnostic purposes. The study revealed that the community of clinical experts is well-informed and in agreement regarding hypophosphatemia management. It emphasized the importance of developing clear national guidance documents to support clinicians and multidisciplinary teams in patient management. These documents are crucial not only for healthcare professionals but also for those responsible for defining pathways and services, facilitating a more accurate management of hypophosphatemic patients.</description><identifier>ISSN: 1720-8386</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-024-02458-4</identifier><identifier>PMID: 39377903</identifier><language>eng</language><publisher>Italy</publisher><ispartof>Journal of endocrinological investigation, 2024-10</ispartof><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-393989abc9707e9a05a0a105eba64d52fbf9ea635a08a4279e359bf16d420e1d3</cites><orcidid>0000-0003-4481-5693 ; 0000-0003-1984-0803 ; 0000-0002-0138-0223 ; 0000-0002-6739-4417 ; 0000-0001-6833-4232 ; 0000-0002-0331-0392 ; 0000-0003-1388-2850 ; 0000-0003-1892-9785 ; 0000-0001-9954-4187 ; 0000-0003-3409-4757 ; 0000-0002-6158-3671 ; 0000-0001-7594-3300 ; 0000-0002-6467-4165 ; 0000-0003-0200-1202</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39377903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiodini, Iacopo</creatorcontrib><creatorcontrib>d'Angela, Daniela</creatorcontrib><creatorcontrib>Falchetti, Alberto</creatorcontrib><creatorcontrib>Gennari, Luigi</creatorcontrib><creatorcontrib>Malavolta, Nazzarena</creatorcontrib><creatorcontrib>Masi, Laura</creatorcontrib><creatorcontrib>Migliore, Antonio</creatorcontrib><creatorcontrib>Orso, Massimiliano</creatorcontrib><creatorcontrib>Polistena, Barbara</creatorcontrib><creatorcontrib>Rendina, Domenico</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><creatorcontrib>Spandonaro, Federico</creatorcontrib><creatorcontrib>Vezzoli, Giuseppe</creatorcontrib><creatorcontrib>Vescini, Fabio</creatorcontrib><creatorcontrib>Delphi Panel Members</creatorcontrib><creatorcontrib>Delphi Panel Members</creatorcontrib><title>Areas of uncertainty on the diagnosis, treatment, and follow-up of hypophosphatemia in adults: an Italian Delphi consensus</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>The study aimed to present the results of a Delphi consensus involving Italian experts focusing on the management of hypophosphatemia in adults. A multidisciplinary advisory board of nine physicians, experts in hypophosphatemia management, was established. Next, a literature search was performed to identify international guidelines, consensus, and clinical pathways, which were later presented to the advisory board. Collaboratively, the advisory board and authoring team selected key statements for the consensus process and focused on areas of uncertainty related to the management of hypophosphatemia. The advisory board also indicated the experts to be invited to participate in the consensus process. The Delphi method was employed to reach a consensus. The literature search yielded one guideline, five consensus documents, and one clinical pathway. While our search strategy aimed to identify documents on the management of all types of hypophosphatemia, most of the guidelines and consensus documents retrieved focused on X-linked hypophosphatemia. The consensus process focused on 11 key issues, achieving strong convergence (over 70% consensus) in the first Delphi round for 8 out of the 11 statements. Three statements proceeded to the second round, with strong agreement reached for two. Notably, consensus was not reached for the statement concerning the measurement of fibroblast growth factor 23 for diagnostic purposes. The study revealed that the community of clinical experts is well-informed and in agreement regarding hypophosphatemia management. It emphasized the importance of developing clear national guidance documents to support clinicians and multidisciplinary teams in patient management. These documents are crucial not only for healthcare professionals but also for those responsible for defining pathways and services, facilitating a more accurate management of hypophosphatemic patients.</description><issn>1720-8386</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpNkEtr3TAQhUVoyfsPZBG0zCJO9LAtq7uQNg8IdNOsxdgexwq25Hhkwu2vr29vGroYzjCccxg-xs6kuJJCmGvKRSmrTKh8O0WV5XvsUBolskpX5Zf_9gN2RPQqhDa6MvvsQFttjBX6kP2-mRGIx44vocE5gQ9pw2PgqUfeengJkTxd8rTa0oghXXIILe_iMMT3bJm2yX4zxamPNPWQcPTAfeDQLkOib6uZPyYY_KrfcZh6z5sYCAMtdMK-djAQnn7oMXu--_Hr9iF7-nn_eHvzlDVKVSlbf7WVhbqxRhi0IAoQIEWBNZR5W6iu7ixCqddzBbkyFnVh606Wba4EylYfs4td7zTHtwUpudFTg8MAAeNCTkuZy0KJQq9WtbM2cySasXPT7EeYN04Kt2Xudszdytv9Ze7yNXT-0b_UI7afkX-Q9R-iXX4v</recordid><startdate>20241008</startdate><enddate>20241008</enddate><creator>Chiodini, Iacopo</creator><creator>d'Angela, Daniela</creator><creator>Falchetti, Alberto</creator><creator>Gennari, Luigi</creator><creator>Malavolta, Nazzarena</creator><creator>Masi, Laura</creator><creator>Migliore, Antonio</creator><creator>Orso, Massimiliano</creator><creator>Polistena, Barbara</creator><creator>Rendina, Domenico</creator><creator>Scillitani, Alfredo</creator><creator>Spandonaro, Federico</creator><creator>Vezzoli, Giuseppe</creator><creator>Vescini, Fabio</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4481-5693</orcidid><orcidid>https://orcid.org/0000-0003-1984-0803</orcidid><orcidid>https://orcid.org/0000-0002-0138-0223</orcidid><orcidid>https://orcid.org/0000-0002-6739-4417</orcidid><orcidid>https://orcid.org/0000-0001-6833-4232</orcidid><orcidid>https://orcid.org/0000-0002-0331-0392</orcidid><orcidid>https://orcid.org/0000-0003-1388-2850</orcidid><orcidid>https://orcid.org/0000-0003-1892-9785</orcidid><orcidid>https://orcid.org/0000-0001-9954-4187</orcidid><orcidid>https://orcid.org/0000-0003-3409-4757</orcidid><orcidid>https://orcid.org/0000-0002-6158-3671</orcidid><orcidid>https://orcid.org/0000-0001-7594-3300</orcidid><orcidid>https://orcid.org/0000-0002-6467-4165</orcidid><orcidid>https://orcid.org/0000-0003-0200-1202</orcidid></search><sort><creationdate>20241008</creationdate><title>Areas of uncertainty on the diagnosis, treatment, and follow-up of hypophosphatemia in adults: an Italian Delphi consensus</title><author>Chiodini, Iacopo ; d'Angela, Daniela ; Falchetti, Alberto ; Gennari, Luigi ; Malavolta, Nazzarena ; Masi, Laura ; Migliore, Antonio ; Orso, Massimiliano ; Polistena, Barbara ; Rendina, Domenico ; Scillitani, Alfredo ; Spandonaro, Federico ; Vezzoli, Giuseppe ; Vescini, Fabio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-393989abc9707e9a05a0a105eba64d52fbf9ea635a08a4279e359bf16d420e1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiodini, Iacopo</creatorcontrib><creatorcontrib>d'Angela, Daniela</creatorcontrib><creatorcontrib>Falchetti, Alberto</creatorcontrib><creatorcontrib>Gennari, Luigi</creatorcontrib><creatorcontrib>Malavolta, Nazzarena</creatorcontrib><creatorcontrib>Masi, Laura</creatorcontrib><creatorcontrib>Migliore, Antonio</creatorcontrib><creatorcontrib>Orso, Massimiliano</creatorcontrib><creatorcontrib>Polistena, Barbara</creatorcontrib><creatorcontrib>Rendina, Domenico</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><creatorcontrib>Spandonaro, Federico</creatorcontrib><creatorcontrib>Vezzoli, Giuseppe</creatorcontrib><creatorcontrib>Vescini, Fabio</creatorcontrib><creatorcontrib>Delphi Panel Members</creatorcontrib><creatorcontrib>Delphi Panel Members</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiodini, Iacopo</au><au>d'Angela, Daniela</au><au>Falchetti, Alberto</au><au>Gennari, Luigi</au><au>Malavolta, Nazzarena</au><au>Masi, Laura</au><au>Migliore, Antonio</au><au>Orso, Massimiliano</au><au>Polistena, Barbara</au><au>Rendina, Domenico</au><au>Scillitani, Alfredo</au><au>Spandonaro, Federico</au><au>Vezzoli, Giuseppe</au><au>Vescini, Fabio</au><aucorp>Delphi Panel Members</aucorp><aucorp>Delphi Panel Members</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Areas of uncertainty on the diagnosis, treatment, and follow-up of hypophosphatemia in adults: an Italian Delphi consensus</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>2024-10-08</date><risdate>2024</risdate><issn>1720-8386</issn><eissn>1720-8386</eissn><abstract>The study aimed to present the results of a Delphi consensus involving Italian experts focusing on the management of hypophosphatemia in adults. A multidisciplinary advisory board of nine physicians, experts in hypophosphatemia management, was established. Next, a literature search was performed to identify international guidelines, consensus, and clinical pathways, which were later presented to the advisory board. Collaboratively, the advisory board and authoring team selected key statements for the consensus process and focused on areas of uncertainty related to the management of hypophosphatemia. The advisory board also indicated the experts to be invited to participate in the consensus process. The Delphi method was employed to reach a consensus. The literature search yielded one guideline, five consensus documents, and one clinical pathway. While our search strategy aimed to identify documents on the management of all types of hypophosphatemia, most of the guidelines and consensus documents retrieved focused on X-linked hypophosphatemia. The consensus process focused on 11 key issues, achieving strong convergence (over 70% consensus) in the first Delphi round for 8 out of the 11 statements. Three statements proceeded to the second round, with strong agreement reached for two. Notably, consensus was not reached for the statement concerning the measurement of fibroblast growth factor 23 for diagnostic purposes. The study revealed that the community of clinical experts is well-informed and in agreement regarding hypophosphatemia management. It emphasized the importance of developing clear national guidance documents to support clinicians and multidisciplinary teams in patient management. These documents are crucial not only for healthcare professionals but also for those responsible for defining pathways and services, facilitating a more accurate management of hypophosphatemic patients.</abstract><cop>Italy</cop><pmid>39377903</pmid><doi>10.1007/s40618-024-02458-4</doi><orcidid>https://orcid.org/0000-0003-4481-5693</orcidid><orcidid>https://orcid.org/0000-0003-1984-0803</orcidid><orcidid>https://orcid.org/0000-0002-0138-0223</orcidid><orcidid>https://orcid.org/0000-0002-6739-4417</orcidid><orcidid>https://orcid.org/0000-0001-6833-4232</orcidid><orcidid>https://orcid.org/0000-0002-0331-0392</orcidid><orcidid>https://orcid.org/0000-0003-1388-2850</orcidid><orcidid>https://orcid.org/0000-0003-1892-9785</orcidid><orcidid>https://orcid.org/0000-0001-9954-4187</orcidid><orcidid>https://orcid.org/0000-0003-3409-4757</orcidid><orcidid>https://orcid.org/0000-0002-6158-3671</orcidid><orcidid>https://orcid.org/0000-0001-7594-3300</orcidid><orcidid>https://orcid.org/0000-0002-6467-4165</orcidid><orcidid>https://orcid.org/0000-0003-0200-1202</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1720-8386
ispartof Journal of endocrinological investigation, 2024-10
issn 1720-8386
1720-8386
language eng
recordid cdi_proquest_miscellaneous_3114152053
source Springer Link
title Areas of uncertainty on the diagnosis, treatment, and follow-up of hypophosphatemia in adults: an Italian Delphi consensus
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T16%3A43%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Areas%20of%20uncertainty%20on%20the%20diagnosis,%20treatment,%20and%20follow-up%20of%20hypophosphatemia%20in%20adults:%20an%20Italian%20Delphi%20consensus&rft.jtitle=Journal%20of%20endocrinological%20investigation&rft.au=Chiodini,%20Iacopo&rft.aucorp=Delphi%20Panel%20Members&rft.date=2024-10-08&rft.issn=1720-8386&rft.eissn=1720-8386&rft_id=info:doi/10.1007/s40618-024-02458-4&rft_dat=%3Cproquest_cross%3E3114152053%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c228t-393989abc9707e9a05a0a105eba64d52fbf9ea635a08a4279e359bf16d420e1d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3114152053&rft_id=info:pmid/39377903&rfr_iscdi=true