Radiomic features on multiparametric MRI for differentiating pseudoprogression from recurrence in high-grade gliomas

• Published in: Acta radiologica (1987) 2024-11, Vol.65 (11), p.1390-1400
• Main Authors: Lin, Jie, Su, Chun-Qiu, Tang, Wen-Tian, Xia, Zhi-Wei, Lu, Shan-Shan, Hong, Xun-Ning
• Format: Article
• Language: English
• Subjects: Adult; Aged; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - pathology; Diagnosis, Differential; Disease Progression; Female; Glioma - diagnostic imaging; Glioma - pathology; Humans; Male; Middle Aged; Multiparametric Magnetic Resonance Imaging - methods; Neoplasm Grading; Neoplasm Recurrence, Local - diagnostic imaging; Radiomics; Retrospective Studies
• ISSN: 0284-1851; 1600-0455; 1600-0455
• DOI: 10.1177/02841851241283781

Background Distinguishing between tumor recurrence and pseudoprogression (PsP) in high-grade glioma postoperatively is challenging. This study aims to enhance this differentiation using a combination of intratumoral and peritumoral radiomics. Purpose To assess the effectiveness of intratumoral and peritumoral radiomics in improving the differentiation between high-grade glioma recurrence and pseudoprogression after surgery. Material and Methods A total of 109 cases were randomly divided into training and validation sets, with 1316 features extracted from intratumoral and peritumoral volumes of interest (VOIs) on conventional magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) maps. Feature selection was performed using the mRMR algorithm, resulting in intratumoral (100 features), peritumoral (100 features), and combined (200 features) subsets. Optimal features were then selected using PCC and RFE algorithms and modeled using LR, SVM, and LDA classifiers. Diagnostic performance was compared using area under the receiver operating characteristic curve (AUC), evaluated in the validation set. A nomogram was established using radscores from intratumoral, peritumoral, and combined models. Results The combined model, utilizing 14 optimal features (8 peritumoral, 6 intratumoral) and LR as the best classifier, outperformed the single intratumoral and peritumoral models. In the training set, the AUC values for the combined model, intratumoral model, and peritumoral model were 0.938, 0.921, and 0.847, respectively; in the validation set, the AUC values were 0.841, 0.755, and 0.705. The nomogram model demonstrated AUCs of 0.960 (training set) and 0.850 (validation set). Conclusion The combination of intratumoral and peritumoral radiomics is effective in distinguishing high-grade glioma recurrence from pseudoprogression after surgery.