Association of tear osmolarity and corneal nerves structure in dry eye disease: an in vivo study

To evaluate the structural changes in corneal sub-basal nerves of dry eye disease (DED) patients with tear hyperosmolarity versus normosmolar tears. A prospective evaluation of the tear film (keratograph 5 M), tear osmolarity, and sub-basal corneal nerves (laser scanning in-vivo confocal microscopy)...

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Published in:Graefe's archive for clinical and experimental ophthalmology 2024-10
Main Authors: Maity, Moumi, Allay, Manindra Bikram, Ali, Mohammed Hasnat, Deshmukh, Rashmi, Basu, Sayan, Singh, Swati
Format: Article
Language:English
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Summary:To evaluate the structural changes in corneal sub-basal nerves of dry eye disease (DED) patients with tear hyperosmolarity versus normosmolar tears. A prospective evaluation of the tear film (keratograph 5 M), tear osmolarity, and sub-basal corneal nerves (laser scanning in-vivo confocal microscopy) was performed in a cohort of 53 DED patients (106 eyes) diagnosed as per DEWS II criteria. Patients with tear hyperosmolarity (Group 1, n = 48 eyes) were compared with DED patients without tear hyperosmolarity (Group 2, n = 58 eyes). Of 53 patients (27 females), 28 had Sjogren's syndrome, and the rest had meibomian gland dysfunction. There were more SS patients (21 vs 7) and females in Group 1. The two groups were similar in age, TMH, NIBUT, meibomian gland loss, bulbar redness, and corneal staining, except for Schirmer I (p 
ISSN:0721-832X
1435-702X
1435-702X
DOI:10.1007/s00417-024-06657-w