The inhibitory influence of carvacrol on behavioral modifications, brain oxidation, and general inflammation triggered by paraquat exposure through inhalation

The current study investigated how carvacrol (C) can prevent behavioral and brain oxidative changes, along with systemic inflammation caused by inhaled paraquat (PQ). Control rats exposed to saline solution, whereas six rat groups were subjected to PQ aerosols at a concentration of 54 mg/m3 in 16 da...

Full description

Saved in:
Bibliographic Details
Published in:Neurotoxicology (Park Forest South) 2024-12, Vol.105, p.184-195
Main Authors: Khosravi, Reyhaneh, Beigoli, Sima, Behrouz, Sepideh, Amirahmadi, Sabiheh, Sarbaz, Parisa, Hosseini, Mahmoud, Sarir, Hadi, Boskabady, Mohammad Hossein
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Behavior, Animal - drug effects
Brain - drug effects
Brain - metabolism
Brian oxidative stress
Carvacrol
Cymenes - pharmacology
Herbicides - toxicity
Inflammation - chemically induced
Inflammation - metabolism
Inhalation Exposure - adverse effects
Learning
Male
Memory
Oxidative Stress - drug effects
Paraquat
Paraquat - toxicity
Rats
Rats, Wistar
Systemic inflammation
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The current study investigated how carvacrol (C) can prevent behavioral and brain oxidative changes, along with systemic inflammation caused by inhaled paraquat (PQ). Control rats exposed to saline solution, whereas six rat groups were subjected to PQ aerosols at a concentration of 54 mg/m3 in 16 days. The PQ-exposed groups received saline (PQ group), C at dosages of 20 (C-L) and 80 mg/kg/day (C-H), dexamethasone at a dosage of 0.03 mg/kg/day, pioglitazone at dose of 5 and 10 mg/kg/day (Pio-L and Pio-H), and a combination of C-L + Pio-L. Various parameters were assessed following the end of the treatment duration. There were marked elevation in total and differential white blood cell counts (WBCs), and malondialdehyde levels in the blood, hippocampus, and cerebral tissue but, thiol, superoxide dismutase (SOD), and catalase (CAT) exhibited a notable decrease (p < 0.05 to p < 0.001). The escape delay and traveled distance exhibited enhancement, however, on the probe day, the duration spent in the target quadrant and the time taken to enter the dark room at 3, 24, 48, and 72 hours post an electrical shock, showed a reduction in the PQ group (P
ISSN:0161-813X
1872-9711
1872-9711
DOI:10.1016/j.neuro.2024.10.003