Advancements and regulations of biomanufacturing cell-based cartilage repair therapies

Cell-based therapies for cartilage repair, including autologous chondrocyte implantation and allogeneic stem cell treatments, show great promise but face challenges due to high costs and regulatory hurdles. This review summarizes available and investigational products, focusing on allogeneic therapi...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2024-10
Main Authors: Tor, Jia Qian, Le, Quang Bach, Ezhilarasu, Hariharan, Chan, Weng Wan, Choudhury, Deepak
Format: Article
Language:English
Subjects:
ACI
cartilage repair
cell therapy
clinical trial
MSC
regulatory
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Summary:Cell-based therapies for cartilage repair, including autologous chondrocyte implantation and allogeneic stem cell treatments, show great promise but face challenges due to high costs and regulatory hurdles. This review summarizes available and investigational products, focusing on allogeneic therapies and the impact of diverse regulatory landscapes on their clinical translation. Cell-based therapies for cartilage repair, including autologous chondrocyte implantation and allogeneic stem cell treatments, show great promise but face challenges due to high costs and regulatory hurdles. This review summarizes available and investigational products, focusing on allogeneic therapies and the impact of diverse regulatory landscapes on their clinical translation.
ISSN:0167-7799
1879-3096
1879-3096
DOI:10.1016/j.tibtech.2024.09.016