Annoglabrin A-C, three new ent-kaurane diterpenoids from the Annona glabra fruit pulp

Three new -kaurane diterpenoids, namely annoglabrin A-C ( ), were isolated from the fruit pulp. Their structures were clarified by widespread spectroscopic analyses (1D and 2D NMR, HRESIMS). The relative configuration of these new compounds was established through the NOESY spectrum. Compounds were...

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Published in:Natural product research 2024-10, p.1-9
Main Authors: Duong, Thi-Kim-Yen, Nguyen, Van-Kieu, Dao, Ngoc-Van-Trang, Bui, Xuan-Hang, Thao, Vo Thi Minh, Nguyen, Minh-Khanh, Dong, Phan-Si-Nguyen, Phan, Hoang-Vinh-Truong, Tran, Thanh-Nha, Ngo, Hoang-Ngoc-Thanh, Mai, Dinh-Tri, Hoang, Le-Thuy-Thuy-Trang
Format: Article
Language:English
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Summary:Three new -kaurane diterpenoids, namely annoglabrin A-C ( ), were isolated from the fruit pulp. Their structures were clarified by widespread spectroscopic analyses (1D and 2D NMR, HRESIMS). The relative configuration of these new compounds was established through the NOESY spectrum. Compounds were evaluated for their inhibitory activity against glucosidase and were found with weak ( and ) or no effects ( ), compared to those of positive control (acarbose, IC 82.0 µM).
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2024.2414397