Paraspinal muscle fibre structural and contractile characteristics demonstrate distinct irregularities in patients with spinal degeneration and deformity

• Published in: European spine journal 2024-12, Vol.33 (12), p.4605-4618
• Main Authors: Noonan, Alex M., Malakoutian, Masoud, Dehghan-Hamani, Iraj, Lewis, Stephen, Street, John, Oxland, Thomas R., Brown, Stephen H. M.
• Format: Article
• Language: English
• Subjects: Actin; Adult; Aged; Biopsy; Degeneration; Female; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Muscle contraction; Muscle Contraction - physiology; Muscle Fibers, Skeletal - pathology; Muscle Fibers, Skeletal - physiology; Neurosurgery; Original Article; Paraspinal Muscles - diagnostic imaging; Paraspinal Muscles - pathology; Paraspinal Muscles - physiopathology; Patients; Surgical Orthopedics
• ISSN: 0940-6719; 1432-0932; 1432-0932
• DOI: 10.1007/s00586-024-08509-x

Background Paraspinal and spinopelvic muscular dysfunction are hypothesized to be a causative factor for spinal degeneration and deformity; however, our fundamental understanding of paraspinal muscle (dys)function remains limited. Methods Twelve surgical patients with spinal degeneration were recruited and categorized into group DEG (four patients) with no sagittal imbalance and no usage of compensatory mechanisms; group DEG-COMP (four patients) with no sagittal imbalance through use of compensatory mechanisms; and group DEG-COMP-UNBAL (four patients) with sagittal imbalance despite use of compensatory mechanisms. From each patient, four biopsies were collected from right and left multifidus (MULT) and longissimus (LONG) for single fibre contractile and structural measurements. Results Eight of 48 (17%) biopsies did not exhibit any contractile properties. Specific force was not different between groups for the MULT ( p  = 0.47) but was greater in group DEG compared to group DEG-COMP-UNBAL for the LONG ( p  = 0.02). Force sarcomere-length properties were unusually variable both within and amongst patients in all groups. Thin filament (actin) lengths were in general shorter and more variable than published norms for human muscle. Conclusion This study is the first to show a heightened intrinsic contractile muscle disorder (i.e. impaired specific force generation) in patients with spinal degeneration who are sagittally imbalanced (compared to patients without deformity). Additionally, there are clear indications that patients with spinal degeneration (all groups) have intrinsic force sarcomere-length properties that are dysregulated. This provides important insight into the pathophysiology of muscle weakness in this patient group.