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Exosomal microRNA as a key regulator of PI3K/AKT pathways in human tumors

MicroRNAs (miRNAs) are conserved non-protein-coding RNAs that are naturally present in organisms and can control gene expression by suppressing the translation of mRNA or causing the degradation of mRNA. MicroRNAs are highly concentrated in the PI3K/AKT pathway, and abnormal activation of the PI3K/A...

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Published in:	Medical oncology (Northwood, London, England) London, England), 2024-10, Vol.41 (11), p.265, Article 265
Main Authors:	Jasim, Saade Abdalkareem, Ahmed, Abdulrahman T., Kubaev, Aziz, Kyada, Ashishkumar, Alshahrani, Mohammad Y., Sharma, Shilpa, Al-Hetty, Hussein Riyadh Abdul Kareem, Vashishth, Raghav, Chauhan, Ashish Singh, Abosaoda, Munther Kadhim
Format:	Article
Language:	English
Subjects:	Cancer Exosomes - genetics Exosomes - metabolism Gene Expression Regulation, Neoplastic Hematology Humans Internal Medicine Medicine Medicine & Public Health MicroRNAs MicroRNAs - genetics Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Pathology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Review Article Signal Transduction
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creator	Jasim, Saade Abdalkareem Ahmed, Abdulrahman T. Kubaev, Aziz Kyada, Ashishkumar Alshahrani, Mohammad Y. Sharma, Shilpa Al-Hetty, Hussein Riyadh Abdul Kareem Vashishth, Raghav Chauhan, Ashish Singh Abosaoda, Munther Kadhim
description	MicroRNAs (miRNAs) are conserved non-protein-coding RNAs that are naturally present in organisms and can control gene expression by suppressing the translation of mRNA or causing the degradation of mRNA. MicroRNAs are highly concentrated in the PI3K/AKT pathway, and abnormal activation of the PI3K/AKT pathway plays a role in cancer progression. The AKT/PI3K pathway is critical for cellular functions and can be stimulated by cytokines and in normal situations. It is involved in regulating various intracellular signal transduction, including development, differentiation, transcriptional regulation, protein, and synthesis. There is a growing body of evidence indicating that miRNAs, which are abundant in exosomes released by different cells, can control cellular biological activities via modulating the PI3K/AKT pathway, hence influencing cancer progression and drug resistance. This article provides an overview of the latest research progress regarding the function and medical use of the PI3K/AKT pathway and exosomal miRNA/AKT/PI3K axis in the behaviors of cancer cells.
doi_str_mv	10.1007/s12032-024-02529-9
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subjects	Cancer Exosomes - genetics Exosomes - metabolism Gene Expression Regulation, Neoplastic Hematology Humans Internal Medicine Medicine Medicine & Public Health MicroRNAs MicroRNAs - genetics Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Pathology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Review Article Signal Transduction
title	Exosomal microRNA as a key regulator of PI3K/AKT pathways in human tumors
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