Effect of diffusivity of amyloid beta monomers on the formation of senile plaques

• Published in: Mathematical medicine and biology 2024-10, Vol.41 (4), p.346
• Main Author: Kuznetsov, Andrey V
• Format: Article
• Language: English
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Computer Simulation; Diffusion; Humans; Kinetics; Mathematical Concepts; Models, Biological; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology
• ISSN: 1477-8599; 1477-8602; 1477-8602
• DOI: 10.1093/imammb/dqae019

Alzheimer's disease (AD) presents a perplexing question: why does its development span decades, even though individual amyloid beta (Aβ) deposits (senile plaques) can form rapidly in as little as 24 hours, as recent publications suggest? This study investigated whether the formation of senile plaques can be limited by factors other than polymerization kinetics alone. Instead, their formation may be limited by the diffusion-driven supply of Aβ monomers, along with the rate at which the monomers are produced from amyloid precursor protein and the rate at which Aβ monomers undergo degradation. A mathematical model incorporating the nucleation and autocatalytic process (via the Finke-Watzky model), as well as Aβ monomer diffusion, was proposed. The obtained system of partial differential equations was solved numerically, and a simplified version was investigated analytically. The computational results predicted that it takes approximately 7 years for Aβ aggregates to reach a neurotoxic concentration of 50 μM. Additionally, a sensitivity analysis was performed to examine how the diffusivity of Aβ monomers and their production rate impact the concentration of Aβ aggregates.