The role of arginase estimation to predict hypertensive disorder of pregnancy at an earlier stage

To determine the significance of serum arginase estimation as a predictor of pregnancy-induced hypertension and preeclampsia at an early stage. The observational, cross-sectional study was conducted from October 15, 2021, to October 15, 2022, at the Department of Chemical Pathology, in collaboration...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2024-10, Vol.74 (10), p.1779-1783
Main Authors: Shafiq, Sabahat, Akbar Khan, Muhammad Nadim, Qayyum, Shazia, Sultana, Saadia
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Amino acids
Arginase
Arginase - blood
Biomarkers - blood
Cross-Sectional Studies
Ethylenediaminetetraacetic acid
Female
Health aspects
Humans
Hypertension
Hypertension in pregnancy
Hypertension, Pregnancy-Induced - blood
Hypertension, Pregnancy-Induced - diagnosis
Hypertension, Pregnancy-Induced - urine
Medical research
Medicine, Experimental
Obstetrical research
Pakistan - epidemiology
Physiological aspects
Platelet Count
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - urine
Pregnancy
Pregnant women
Proteinuria - diagnosis
Sapropterin dihydrochloride
Uric Acid - blood
Young Adult
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Summary:To determine the significance of serum arginase estimation as a predictor of pregnancy-induced hypertension and preeclampsia at an early stage. The observational, cross-sectional study was conducted from October 15, 2021, to October 15, 2022, at the Department of Chemical Pathology, in collaboration with the Department of Obstetrics and Gynaecology, Pakistan Railway Hospital, Islamic International Medical College Trust, Rawalpindi, Pakistan, and comprised pregnant women with 20-25 weeks of gestation who were divided into three groups. Those having no complications were placed in control group A, those with pregnancy-induced hypertension in group B, and those with preeclampsia in group C. Serum arginase, uric acid, alanine transaminase, platelet count and spot urinary protein levels were measured for each subject. Data was analysed using SPSS 26. Of the 90 women, 30(33.3%) were in group A with mean age 27.27±2.90 years, 30(33.3%) were in group B with mean age 30.17±2.48 years, and 30(33.3%) were in group C with mean age 29.33±3.11 years. There were significant intergroup differences in the mean levels of serum arginase, serum uric acid, alanine transaminase, platelet count and spot urinary protein (p
ISSN:0030-9982
0030-9982
DOI:10.47391/JPMA.10157