Correlation between lncRNAs with human molecular chaperons in cancer immunopathogenesis and drug resistance

• Published in: International immunopharmacology 2024-12, Vol.143 (Pt 1), p.113309, Article 113309
• Main Authors: Hsu, Chou-Yi, Hisham Ateya, Nabaa, Felix Oghenemaro, Enwa, Nathiya, Deepak, Kaur, Parjinder, Hjazi, Ahmed, Eldesoqui, Mamdouh, Yumashev, Alexey, Kadhim Abosaoda, Munther, Adnan Abdulrahman, Mustafa
• Format: Article
• Language: English
• Subjects: Cancer; Chaperons; Drug resistance; Immunopathogenesis; lncRNA
• ISSN: 1567-5769; 1878-1705; 1878-1705
• DOI: 10.1016/j.intimp.2024.113309

•lncRNAs-chaperones interaction is significantly involved in cancer immunopathogenesis.•lncRNAs interact with chaperones, affecting cancer-causing pathways through gene regulation processes.•lncRNAs’ interaction with chaperones affects cellular processes and cancer drug resistance.•lncRNAs-chaperones cooperation affects immune and tumor cells within the tumor microenvironment. The development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves. Understanding these mechanisms provides valuable insights into innovative approaches for diagnosis and treatment. Targeting the lncRNA-chaperone axis has the potential to strengthen anti-tumor immunity and enhance cancer treatment outcomes. Further research is necessary to uncover specific associations, identify biomarkers, and develop personalized therapies aimed at disrupting this axis, which could potentially revolutionize cancer diagnosis and treatment.