Monomelittoside and Dichotomoside D from bark extract of Alstonia scholaris (L.) R. Br. inhibits dental caries pathogen Streptococcus mutans

Dental caries advances to be a significant global health concern, primarily attributed to the virulent actions of . The antibacterial property of the bark extract of was assessed using standard disc diffusion assays, which revealed significant inhibition of . Subsequently, we determined the Minimum...

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Published in:Natural product research 2024-10, p.1-6
Main Authors: Rao, Anupama, Kumar B, Sukesh, Fareena, Zaynab, Khan, Husna, Shastry, Rajesh P, Rani N, Megha
Format: Article
Language:English
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Summary:Dental caries advances to be a significant global health concern, primarily attributed to the virulent actions of . The antibacterial property of the bark extract of was assessed using standard disc diffusion assays, which revealed significant inhibition of . Subsequently, we determined the Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) revealed potent antibacterial activity of bark extract against , at MIC and MBC values 62.5 and 125 µg/mL, respectively and antibiofilm activity at 125 µg/mL. Furthermore, cytotoxicity assays showed no adverse effects on mammalian cells. Moreover, we employed liquid chromatography-mass spectrometry to identify bioactive compounds in the bark extract and revealed the presence of major active compounds as Monomelittoside and Dichotomoside D effective in targeting the . These findings showed that, the promising antibacterial efficacy of Monomelittoside and Dichotomoside D, highlighting their potential as natural therapeutics for combating dental caries.
ISSN:1478-6419
1478-6427
1478-6427
DOI:10.1080/14786419.2024.2413929