Is severe carbohydrate restriction necessary for appetite suppression? The ASKED randomized controlled trial

• Published in: Obesity (Silver Spring, Md.) Md.), 2024-11, Vol.32 (11), p.2087-2099
• Main Authors: Roekenes, Jessica A., Aukan, Marthe I., Bomo, Ola Jakob, Brechan, Ingeborg, Knudsen, Katarina A., Hansen, Jonas G., Coutinho, Sílvia R., Rehfeld, Jens F., Truby, Helen, Sainsbury, Amanda, Svendsen, Mette, Martins, Catia
• Format: Article
• Language: English
• Subjects: 3-Hydroxybutyric Acid - blood; Adult; Appetite; Appetite Regulation; Body Composition; Body Mass Index; Diet, Carbohydrate-Restricted - methods; Diet, Reducing - methods; Dietary Carbohydrates - administration & dosage; Energy Intake; Female; Humans; Hunger; Ketosis; Male; Middle Aged; Obesity - diet therapy; Weight Loss
• ISSN: 1930-7381; 1930-739X; 1930-739X
• DOI: 10.1002/oby.24133

Objective This trial aimed to compare three low‐energy diets (LEDs) with different amounts of carbohydrates (CHO) on ketosis and changes in hunger feelings in adults with obesity. Methods A total of 101 adults (51 female) with obesity (BMI, mean [SEM], 34.7 [0.4] kg/m2) were randomized to follow three isocaloric LEDs (1000 kcal/day) for 8 weeks, containing either low, medium, or high CHO (70, 100, and 130 g/day, respectively), and 4 weeks of refeeding and weight stabilization. Body weight (BW) and composition, hunger and other appetite ratings, concentrations of β‐hydroxybutyrate (βHB), and appetite‐related hormones were measured at baseline and at the end of weeks 8 and 12. Results At week 8, weight loss and βHB concentrations were significantly different among groups: Low CHO group versus Medium CHO group (BW: 2.32 [0.95] kg, 95% CI: 0.44 to 4.21, p = 0.016; βHB: −0.40 [0.09] mM, 95% CI: −0.67 to −0.09, p