Effect of oral doxycycline, azithromycin and isotretinoin on haematological inflammatory markers and interleukin-17A levels in acne vulgaris: a single blinded randomised interventional study

Amidst the existing literature on the effect of isotretinoin on serum interleukin-17 levels in acne patients, the effects of oral antibiotics azithromycin and doxycycline on serum interleukin-17 is scarce. We conducted an investigator blinded randomized interventional study to compare the effect of...

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Bibliographic Details
Published in:Archives of dermatological research 2024-10, Vol.316 (10), p.697, Article 697
Main Authors: Agrawal, Akriti, Bhardwaj, Abhishek, Singh, Saurabh, Budania, Anil, Bains, Anupama, Sharma, Shailja, Purohit, Abhishek, Rajan M, Bandhala, Rajagopal, Varun
Format: Article
Language:English
Subjects:
Acne
Acne Vulgaris - blood
Acne Vulgaris - drug therapy
Administration, Oral
Adolescent
Adult
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Antibiotics
Azithromycin
Azithromycin - administration & dosage
Azithromycin - therapeutic use
Biomarkers - blood
Cytokines
Dermatologic Agents - administration & dosage
Dermatologic Agents - therapeutic use
Dermatology
Doxycycline
Doxycycline - administration & dosage
Doxycycline - therapeutic use
Female
Humans
Inflammation
Interleukin 17
Interleukin-17 - blood
Isotretinoin - administration & dosage
Isotretinoin - therapeutic use
Leukocytes (neutrophilic)
Lymphocytes
Male
Medicine
Medicine & Public Health
Original Paper
Patients
Platelets
Single-Blind Method
Statistical analysis
Treatment Outcome
Young Adult
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Summary:Amidst the existing literature on the effect of isotretinoin on serum interleukin-17 levels in acne patients, the effects of oral antibiotics azithromycin and doxycycline on serum interleukin-17 is scarce. We conducted an investigator blinded randomized interventional study to compare the effect of doxycycline, azithromycin and isotretinoin on inflammatory markers and Interleukin-17A (IL-17A) levels in acne. Patients were randomized and received the treatment according to treatment arm till 12 weeks. At baseline and 12 weeks/treatment completion, clinical improvement and Red-cell-distribution width (RDW),Neutrophil-lymphocyte ratio(NLR),Platelet-lymphocyte ratio(PLR), Mean-Platelet volume(MPV), Platelet-distribution width(PDW) and Interleukin-17A levels were analysed. P -value 
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-024-03434-x