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Effect of oral doxycycline, azithromycin and isotretinoin on haematological inflammatory markers and interleukin-17A levels in acne vulgaris: a single blinded randomised interventional study
Amidst the existing literature on the effect of isotretinoin on serum interleukin-17 levels in acne patients, the effects of oral antibiotics azithromycin and doxycycline on serum interleukin-17 is scarce. We conducted an investigator blinded randomized interventional study to compare the effect of...
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| Published in: | Archives of dermatological research 2024-10, Vol.316 (10), p.697, Article 697 |
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| creator | Agrawal, Akriti Bhardwaj, Abhishek Singh, Saurabh Budania, Anil Bains, Anupama Sharma, Shailja Purohit, Abhishek Rajan M, Bandhala Rajagopal, Varun |
| description | Amidst the existing literature on the effect of isotretinoin on serum interleukin-17 levels in acne patients, the effects of oral antibiotics azithromycin and doxycycline on serum interleukin-17 is scarce. We conducted an investigator blinded randomized interventional study to compare the effect of doxycycline, azithromycin and isotretinoin on inflammatory markers and Interleukin-17A (IL-17A) levels in acne. Patients were randomized and received the treatment according to treatment arm till 12 weeks. At baseline and 12 weeks/treatment completion, clinical improvement and Red-cell-distribution width (RDW),Neutrophil-lymphocyte ratio(NLR),Platelet-lymphocyte ratio(PLR), Mean-Platelet volume(MPV), Platelet-distribution width(PDW) and Interleukin-17A levels were analysed.
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| doi_str_mv | 10.1007/s00403-024-03434-x |
| format | article |
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P
-value < 0.05 was considered statistically significant. Out of 120 patients, 110 patients completed the study. Baseline Global acne grading scale (GAGS) in doxycycline, azithromycin or isotretinoin group was 24.32 ± 3.119, 24.12 ± 2.804 and 25.10 ± 3.985 respectively and post-treatment was 5.216 ± 1.88, 7.265 ± 2.17 and 2.769 ± 1.08. All the drugs caused a statistically significant decrease in RDW and IL-17 A levels. Baseline levels of IL-17 A were significantly higher in patients with higher GAGS and post-acne scarring. One of the limitations of our study was that we excluded severe nodulocystic acne patients thereby these results have to be carefully extrapolated.</description><identifier>ISSN: 1432-069X</identifier><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-024-03434-x</identifier><identifier>PMID: 39417892</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject><![CDATA[Acne ; Acne Vulgaris - blood ; Acne Vulgaris - drug therapy ; Administration, Oral ; Adolescent ; Adult ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Azithromycin ; Azithromycin - administration & dosage ; Azithromycin - therapeutic use ; Biomarkers - blood ; Cytokines ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - therapeutic use ; Dermatology ; Doxycycline ; Doxycycline - administration & dosage ; Doxycycline - therapeutic use ; Female ; Humans ; Inflammation ; Interleukin 17 ; Interleukin-17 - blood ; Isotretinoin - administration & dosage ; Isotretinoin - therapeutic use ; Leukocytes (neutrophilic) ; Lymphocytes ; Male ; Medicine ; Medicine & Public Health ; Original Paper ; Patients ; Platelets ; Single-Blind Method ; Statistical analysis ; Treatment Outcome ; Young Adult]]></subject><ispartof>Archives of dermatological research, 2024-10, Vol.316 (10), p.697, Article 697</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-a54c035c700d4016a9ca481da0d5cbbc6aab0da8f1cbdd73e57701ce0f28cd913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39417892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agrawal, Akriti</creatorcontrib><creatorcontrib>Bhardwaj, Abhishek</creatorcontrib><creatorcontrib>Singh, Saurabh</creatorcontrib><creatorcontrib>Budania, Anil</creatorcontrib><creatorcontrib>Bains, Anupama</creatorcontrib><creatorcontrib>Sharma, Shailja</creatorcontrib><creatorcontrib>Purohit, Abhishek</creatorcontrib><creatorcontrib>Rajan M, Bandhala</creatorcontrib><creatorcontrib>Rajagopal, Varun</creatorcontrib><title>Effect of oral doxycycline, azithromycin and isotretinoin on haematological inflammatory markers and interleukin-17A levels in acne vulgaris: a single blinded randomised interventional study</title><title>Archives of dermatological research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>Amidst the existing literature on the effect of isotretinoin on serum interleukin-17 levels in acne patients, the effects of oral antibiotics azithromycin and doxycycline on serum interleukin-17 is scarce. We conducted an investigator blinded randomized interventional study to compare the effect of doxycycline, azithromycin and isotretinoin on inflammatory markers and Interleukin-17A (IL-17A) levels in acne. Patients were randomized and received the treatment according to treatment arm till 12 weeks. At baseline and 12 weeks/treatment completion, clinical improvement and Red-cell-distribution width (RDW),Neutrophil-lymphocyte ratio(NLR),Platelet-lymphocyte ratio(PLR), Mean-Platelet volume(MPV), Platelet-distribution width(PDW) and Interleukin-17A levels were analysed.
P
-value < 0.05 was considered statistically significant. Out of 120 patients, 110 patients completed the study. Baseline Global acne grading scale (GAGS) in doxycycline, azithromycin or isotretinoin group was 24.32 ± 3.119, 24.12 ± 2.804 and 25.10 ± 3.985 respectively and post-treatment was 5.216 ± 1.88, 7.265 ± 2.17 and 2.769 ± 1.08. All the drugs caused a statistically significant decrease in RDW and IL-17 A levels. Baseline levels of IL-17 A were significantly higher in patients with higher GAGS and post-acne scarring. One of the limitations of our study was that we excluded severe nodulocystic acne patients thereby these results have to be carefully extrapolated.</description><subject>Acne</subject><subject>Acne Vulgaris - blood</subject><subject>Acne Vulgaris - drug therapy</subject><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Azithromycin</subject><subject>Azithromycin - administration & dosage</subject><subject>Azithromycin - therapeutic use</subject><subject>Biomarkers - blood</subject><subject>Cytokines</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Dermatology</subject><subject>Doxycycline</subject><subject>Doxycycline - administration & dosage</subject><subject>Doxycycline - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 17</subject><subject>Interleukin-17 - blood</subject><subject>Isotretinoin - administration & dosage</subject><subject>Isotretinoin - therapeutic use</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Platelets</subject><subject>Single-Blind Method</subject><subject>Statistical analysis</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1432-069X</issn><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhSMEoqXwAiyQJTYsCL2OnThhV1XlR6rEpkjsIse-mbp17GI7owkPx7PVQ4aCWLCydf2dc498iuIlhXcUQJxGAA6shIqXwDjj5e5RcUw5q0poum-P_7ofFc9ivIEsEi19WhyxjlPRdtVx8fNiHFEl4kfig7RE-92iFmWNw7dE_jDpOvhpUcYR6TQx0aeAyTifB96Ra4mTTN76jVFZbNxo5bSfhIVMMtxiiKvOJQwW51vjSirOiMUt2kj2rsoh2c52I4OJ74kk0biNRTLkBBo1CVnuJxPxYLJFl4x3eVlMs16eF09GaSO-OJwnxdcPF1fnn8rLLx8_n59dlqqqm1TKmitgtRIAmgNtZKckb6mWoGs1DKqRcgAt25GqQWvBsBYCqEIYq1bpjrKT4s3qexf89xlj6nMmhdZKh36OPaNUNLRuqMjo63_QGz-HnHilOsFqXmWqWikVfIwBx_4umPxlS0-h37fbr-32ud3-V7v9LoteHaznYUL9IPldZwbYCsT85DYY_uz-j-09ITS2Yg</recordid><startdate>20241017</startdate><enddate>20241017</enddate><creator>Agrawal, Akriti</creator><creator>Bhardwaj, Abhishek</creator><creator>Singh, Saurabh</creator><creator>Budania, Anil</creator><creator>Bains, Anupama</creator><creator>Sharma, Shailja</creator><creator>Purohit, Abhishek</creator><creator>Rajan M, Bandhala</creator><creator>Rajagopal, Varun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20241017</creationdate><title>Effect of oral doxycycline, azithromycin and isotretinoin on haematological inflammatory markers and interleukin-17A levels in acne vulgaris: a single blinded randomised interventional study</title><author>Agrawal, Akriti ; Bhardwaj, Abhishek ; Singh, Saurabh ; Budania, Anil ; Bains, Anupama ; Sharma, Shailja ; Purohit, Abhishek ; Rajan M, Bandhala ; Rajagopal, Varun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-a54c035c700d4016a9ca481da0d5cbbc6aab0da8f1cbdd73e57701ce0f28cd913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acne</topic><topic>Acne Vulgaris - blood</topic><topic>Acne Vulgaris - drug therapy</topic><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Azithromycin</topic><topic>Azithromycin - administration & dosage</topic><topic>Azithromycin - therapeutic use</topic><topic>Biomarkers - blood</topic><topic>Cytokines</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Dermatology</topic><topic>Doxycycline</topic><topic>Doxycycline - administration & dosage</topic><topic>Doxycycline - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 17</topic><topic>Interleukin-17 - blood</topic><topic>Isotretinoin - administration & dosage</topic><topic>Isotretinoin - therapeutic use</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Platelets</topic><topic>Single-Blind Method</topic><topic>Statistical analysis</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agrawal, Akriti</creatorcontrib><creatorcontrib>Bhardwaj, Abhishek</creatorcontrib><creatorcontrib>Singh, Saurabh</creatorcontrib><creatorcontrib>Budania, Anil</creatorcontrib><creatorcontrib>Bains, Anupama</creatorcontrib><creatorcontrib>Sharma, Shailja</creatorcontrib><creatorcontrib>Purohit, Abhishek</creatorcontrib><creatorcontrib>Rajan M, Bandhala</creatorcontrib><creatorcontrib>Rajagopal, Varun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agrawal, Akriti</au><au>Bhardwaj, Abhishek</au><au>Singh, Saurabh</au><au>Budania, Anil</au><au>Bains, Anupama</au><au>Sharma, Shailja</au><au>Purohit, Abhishek</au><au>Rajan M, Bandhala</au><au>Rajagopal, Varun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of oral doxycycline, azithromycin and isotretinoin on haematological inflammatory markers and interleukin-17A levels in acne vulgaris: a single blinded randomised interventional study</atitle><jtitle>Archives of dermatological research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2024-10-17</date><risdate>2024</risdate><volume>316</volume><issue>10</issue><spage>697</spage><pages>697-</pages><artnum>697</artnum><issn>1432-069X</issn><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Amidst the existing literature on the effect of isotretinoin on serum interleukin-17 levels in acne patients, the effects of oral antibiotics azithromycin and doxycycline on serum interleukin-17 is scarce. We conducted an investigator blinded randomized interventional study to compare the effect of doxycycline, azithromycin and isotretinoin on inflammatory markers and Interleukin-17A (IL-17A) levels in acne. Patients were randomized and received the treatment according to treatment arm till 12 weeks. At baseline and 12 weeks/treatment completion, clinical improvement and Red-cell-distribution width (RDW),Neutrophil-lymphocyte ratio(NLR),Platelet-lymphocyte ratio(PLR), Mean-Platelet volume(MPV), Platelet-distribution width(PDW) and Interleukin-17A levels were analysed.
P
-value < 0.05 was considered statistically significant. Out of 120 patients, 110 patients completed the study. Baseline Global acne grading scale (GAGS) in doxycycline, azithromycin or isotretinoin group was 24.32 ± 3.119, 24.12 ± 2.804 and 25.10 ± 3.985 respectively and post-treatment was 5.216 ± 1.88, 7.265 ± 2.17 and 2.769 ± 1.08. All the drugs caused a statistically significant decrease in RDW and IL-17 A levels. Baseline levels of IL-17 A were significantly higher in patients with higher GAGS and post-acne scarring. One of the limitations of our study was that we excluded severe nodulocystic acne patients thereby these results have to be carefully extrapolated.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39417892</pmid><doi>10.1007/s00403-024-03434-x</doi></addata></record> |
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| subjects | Acne Acne Vulgaris - blood Acne Vulgaris - drug therapy Administration, Oral Adolescent Adult Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibiotics Azithromycin Azithromycin - administration & dosage Azithromycin - therapeutic use Biomarkers - blood Cytokines Dermatologic Agents - administration & dosage Dermatologic Agents - therapeutic use Dermatology Doxycycline Doxycycline - administration & dosage Doxycycline - therapeutic use Female Humans Inflammation Interleukin 17 Interleukin-17 - blood Isotretinoin - administration & dosage Isotretinoin - therapeutic use Leukocytes (neutrophilic) Lymphocytes Male Medicine Medicine & Public Health Original Paper Patients Platelets Single-Blind Method Statistical analysis Treatment Outcome Young Adult |
| title | Effect of oral doxycycline, azithromycin and isotretinoin on haematological inflammatory markers and interleukin-17A levels in acne vulgaris: a single blinded randomised interventional study |
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