Glycolytic reprogramming in microglia: A potential therapeutic target for ischemic stroke

Ischemic stroke is currently the second leading cause of mortality worldwide, with limited treatment options available. As resident immune cells, microglia promptly respond to cerebral ischemic injury, influencing neuroinflammatory damage and neurorepair. Studies suggest that microglia undergo metab...

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Bibliographic Details
Published in:Cellular signalling 2024-12, Vol.124, p.111466, Article 111466
Main Authors: Zhang, Guangming, Zhao, Anliu, Zhang, Xiaolu, Zeng, Miao, Wei, Huayuan, Yan, Xu, Wang, Jie, Jiang, Xijuan, Dai, Yongna
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - metabolism
Cellular Reprogramming
Glycolysis
Glycolysis - drug effects
Humans
Ischemic stroke
Ischemic Stroke - metabolism
Ischemic Stroke - pathology
Microglia
Microglia - metabolism
Mitochondria - metabolism
Neuroinflammation
Oxidative Phosphorylation - drug effects
Polarization
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Summary:Ischemic stroke is currently the second leading cause of mortality worldwide, with limited treatment options available. As resident immune cells, microglia promptly respond to cerebral ischemic injury, influencing neuroinflammatory damage and neurorepair. Studies suggest that microglia undergo metabolic reprogramming from mitochondrial oxidative phosphorylation to glycolysis in response to ischemia, significantly impacting their function during ischemic stroke. Therefore, this study aims to investigate the roles and regulatory mechanisms involved in this process, aiming to identify a new therapeutic target or potential drug candidate. [Display omitted] •In ischemic stroke condition, activated microglia undergo metabolic reprogramming.•The glycolysis-related enzymes and molecules regulate the microglial phenotype.•Microglial glycolysis affects the multiple functions of microglia in ischemic stroke.•Targeting microglial glycolysis is helpful in developing drug for ischemic stroke.
ISSN:0898-6568
1873-3913
1873-3913
DOI:10.1016/j.cellsig.2024.111466