Nutrigenomics-guided lifestyle intervention programmes: A critical scoping review with directions for future research

Genetic testing is increasingly used in clinical practice to provide personalized information and recommendations about health risks and lifestyle habits at a relatively low cost. Research on the effectiveness of nutrigenomics-guided lifestyle interventions is growing. A scoping review approach was...

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Bibliographic Details
Published in:Clinical nutrition ESPEN 2024-12, Vol.64, p.296-306
Main Authors: Aljasir, Saba, Eid, Noura M.S., Volpi, Emanuela V., Tewfik, Ihab
Format: Article
Language:English
Subjects:
Gene expression
Genetic Testing
Humans
Life Style
Nutrigenetics
Nutrigenomics
Nutrition intervention
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Summary:Genetic testing is increasingly used in clinical practice to provide personalized information and recommendations about health risks and lifestyle habits at a relatively low cost. Research on the effectiveness of nutrigenomics-guided lifestyle interventions is growing. A scoping review approach was adopted to identify pertinent published studies on nutrigenomics-guided intervention programmes from 2007 to 2023. The review shows that despite the growing interest in nutrigenomics-guided lifestyle interventions, there are still few empirically supported studies, primarily based on developed countries. Furthermore, the findings on the impact of personalised genetic advice are mixed, leaving the field unclear. Existing studies have some empirical strength, contributing to further understanding of the relationship between food and gene expression. However, some limitations that affect the robustness of findings exist, such as a small sample size, insufficient monitoring of the data collection process, and a short follow-up period. Future research needs to address reliability concerns and provide more robust practical evidence.
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2024.10.149