The interplay between histone modifications and nuclear lamina in genome regulation

Gene expression is regulated by chromatin architecture and epigenetic remodeling in cell homeostasis and pathologies. Histone modifications act as the key factors to modulate the chromatin accessibility. Different histone modifications are strongly associated with the localization of chromatin. Hete...

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Bibliographic Details
Published in:Journal of genetics and genomics 2025-01, Vol.52 (1), p.24-38
Main Authors: Sun, Chang, Zhao, Yanjing, Guo, Liping, Qiu, Juhui, Peng, Qin
Format: Article
Language:English
Subjects:
Cell differentiation
Chromatin organization
Genome regulation
Histone modifications
Lamina-associated domain
Nuclear lamina
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Summary:Gene expression is regulated by chromatin architecture and epigenetic remodeling in cell homeostasis and pathologies. Histone modifications act as the key factors to modulate the chromatin accessibility. Different histone modifications are strongly associated with the localization of chromatin. Heterochromatin primarily localizes at the nuclear periphery, where it interacts with lamina proteins to suppress gene expression. In this review, we summarize the potential bridges that have regulatory functions of histone modifications in chromatin organization and transcriptional regulation at the nuclear periphery. We use lamina-associated domains (LADs) as examples to elucidate the biological roles of the interactions between histone modifications and nuclear lamina in cell differentiation and development. In the end, we highlight the technologies that are currently used to identify and visualize histone modifications and LADs, which could provide spatiotemporal information for understanding their regulatory functions in gene expression and discovering new targets for diseases.
ISSN:1673-8527
DOI:10.1016/j.jgg.2024.10.005