The impact of anti-tuberculosis treatment on respiratory tract microbiome in pulmonary tuberculosis

The growing evidence has underscored the significance of interactions between the host and microbiota in respiratory health, presenting a novel perspective on disease management. Yet, comprehension of the respiratory microbiome shifts before and after anti-tuberculosis treatment is limited. This stu...

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Bibliographic Details
Published in:Microbes and infection 2024-10, p.105432, Article 105432
Main Authors: Hazra, Druti, Chawla, Kiran, S.M., Fayaz, Sintchenko, Vitali, Magazine, Rahul, Martinez, Elena, Pandey, Akhilesh
Format: Article
Language:English
Subjects:
16S metagenomics
Anti-tuberculosis treatment
Respiratory microbiome
Sputum
Tuberculosis
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Summary:The growing evidence has underscored the significance of interactions between the host and microbiota in respiratory health, presenting a novel perspective on disease management. Yet, comprehension of the respiratory microbiome shifts before and after anti-tuberculosis treatment is limited. This study compares respiratory microbiome profiles in untreated tuberculosis (UTB) and completed TB treatment (CTB) cases with healthy controls, using 16S rRNA sequencing on sputum samples. Significant reduction in sputum microbial alpha diversity was observed in both TB groups when compared to healthy controls (P 
ISSN:1286-4579
1769-714X
1769-714X
DOI:10.1016/j.micinf.2024.105432