Influence of scleral thickness on photodynamic therapy outcomes in central serous chorioretinopathy

• Published in: Acta ophthalmologica (Oxford, England) England), 2024-10
• Main Authors: Forte, Paolo, Cattaneo, Jennifer, Cardillo Piccolino, Felice, Arrigo, Alessandro, Corazza, Paolo, Musetti, Donatella, Rosa, Raffaella, Traverso, Carlo Enrico, Fontana, Vincenzo, Lupidi, Marco, Eandi, Chiara Maria, Nicolò, Massimo
• Format: Article
• Language: English
• ISSN: 1755-375X; 1755-3768; 1755-3768
• DOI: 10.1111/aos.16779

To test the prognostic role of anterior scleral substantia propria (ASSP) thickness in predicting the 3-month response after half-dose photodynamic therapy (PDT) in central serous chorioretinopathy (CSCR) and to assess its clinical relevance of ASSP in different CSCR phenotypes. A prospective, exploratory, multi-centre cohort study conducted at IRCCS San Martino Hospital (Genoa, Italy) and Jules-Gonin Eye Hospital (Lausanne, Switzerland). Demographic and clinical data, and optical coherence tomography (OCT) were collected at baseline and 3 months after PDT. Based on OCT images, we categorized CSCR phenotypes and collected clinically relevant imaging metrics. ASSP thickness was obtained from four different measurements using anterior segment (AS) OCT. Multivariable regression models were performed to evaluate the distribution of ASSP thicknesses among different CSCR phenotypes and to test the prognostic role of ASSP thickness in discriminating between PDT responders (complete subretinal fluid reabsorption) and partial responders. The study cohort comprised 109 Caucasian patients (82 males, 75.2%) with a total of 142 eyes: 84 eyes simple (59.1%) versus 58 eyes complex (40.9%) CSCR. A linear normal model confirmed a positive association between complex CSCR and higher ASSP thickness (β = 26.1, 95% CL = 12.1/40.1, p