Apolipoprotein B-48 and late graft failure in kidney transplant recipients

Introduction Transplant vasculopathy resembles atherosclerotic plaque formation and is a major contributor to late graft failure in kidney transplant recipients (KTR). Remnant lipoproteins and associated triglycerides are causal risk factors for atherosclerotic plaques and have been implicated in la...

Full description

Saved in:
Bibliographic Details
Published in:Clinical kidney journal 2024-10, Vol.17 (10), p.sfae289
Main Authors: Szili-Torok, Tamas, de Borst, Martin H, Soteriou, Alexandra, Post, Laura, Bakker, Stephan J L, Tietge, Uwe J F
Format: Article
Language:English
Subjects:
Apolipoproteins
Complications
Health aspects
Kidneys
Physiological aspects
Surgery
Transplantation
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Transplant vasculopathy resembles atherosclerotic plaque formation and is a major contributor to late graft failure in kidney transplant recipients (KTR). Remnant lipoproteins and associated triglycerides are causal risk factors for atherosclerotic plaques and have been implicated in late kidney graft failure. However, whether remnants derived from liver (containing apolipoprotein [apo] B100) or intestine (containing apoB48) are clinically more important is unclear. The current study investigated the association between baseline fasting apoB48 levels and late kidney graft failure. Methods 481 KTR with a functioning graft for at least 1 year were included in this retrospective, observational longitudinal single center cohort study. The primary endpoint was death-censored late graft failure, defined as need for initiation of dialysis or re-transplantation. ApoB48 was measured by enzyme-linked immunosorbent assay. Results During a median follow-up of 9.5 years, 61 KTR developed graft failure (12.7%). At baseline, KTR with higher apoB48 levels had lower eGFR (P 
ISSN:2048-8505
2048-8513
DOI:10.1093/ckj/sfae289