Cholesterol-Supported Liquid-Phase Synthesis of Betaines and Organic Cations without Chromatography

Cholesterol was explored as a support for liquid-phase synthesis. Without the need for chromatography, the cholesterol-supported liquid-phase approach gave access to diverse betaines possessing chiral ammonium, phosphonium, and sulfonium ions. The cholesterol-supported method was further demonstrate...

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Bibliographic Details
Published in:Organic letters 2024-11, Vol.26 (43), p.9233-9236
Main Authors: Maarouf Mesli, Nassim, Chaurand, Pierre, Lubell, William D.
Format: Article
Language:English
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Summary:Cholesterol was explored as a support for liquid-phase synthesis. Without the need for chromatography, the cholesterol-supported liquid-phase approach gave access to diverse betaines possessing chiral ammonium, phosphonium, and sulfonium ions. The cholesterol-supported method was further demonstrated by the synthesis of cationic amides and hydrazides.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.4c03336