Application of hydrogel-loaded dental stem cells in the field of tissue regeneration

Mesenchymal stem cells (MSCs) are highly favored in clinical trials due to their unique characteristics, which have isolated from various human tissues. Derived from dental tissues, dental stem cells (DSCs) are particularly notable for their applications in tissue repair and regenerative medicine, a...

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Published in:Human cell : official journal of Human Cell Research Society 2024-10, Vol.38 (1), p.2, Article 2
Main Authors: Wang, Xiaolan, Zheng, Zejun, Zhang, Ying, Sun, Jinmeng, Liu, Jian, Liu, Yunxia, Ding, Gang
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Biology
Cell Differentiation
Cell therapy
Clinical trials
Dental restorative materials
Gynecology
Humans
Hydrogels
Immunogenicity
Life Sciences
Mesenchymal stem cells
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - physiology
Oncology
Regeneration
Regenerative medicine
Regenerative Medicine - methods
Reproductive Medicine
Review Article
Stem Cells
Stem Cells - cytology
Stem Cells - physiology
Surgery
Tissue Engineering - methods
Tooth - cytology
Tooth - physiology
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Summary:Mesenchymal stem cells (MSCs) are highly favored in clinical trials due to their unique characteristics, which have isolated from various human tissues. Derived from dental tissues, dental stem cells (DSCs) are particularly notable for their applications in tissue repair and regenerative medicine, attributed to their readily available sources, absence of ethical controversies, and minimal immunogenicity. Hydrogel-loaded stem cell therapy is widespread across a variety of injuries and diseases, and has good repair capabilities for both soft and hard tissues. This review comprehensively summarizes the regenerative and differentiation potential of various DSCs encapsulated in hydrogels across different tissues. In addition, the existing problems and future direction are also addressed. The application of hydrogel–DSCs composite has gained substantial progress in the field of tissue regeneration and need in-depth study in the future.
ISSN:1749-0774
0914-7470
1749-0774
DOI:10.1007/s13577-024-01134-2