EnteroBase in 2025: exploring the genomic epidemiology of bacterial pathogens

• Published in: Nucleic acids research 2025-01, Vol.53 (D1), p.D757-D762
• Main Authors: Dyer, Nigel P, Päuker, Birgitta, Baxter, Laura, Gupta, Anshul, Bunk, Boyke, Overmann, Jörg, Diricks, Margo, Dreyer, Viola, Niemann, Stefan, Holt, Kathryn E, Rahman, Mohammed, Brown, Paul E, Stark, Richard, Zhou, Zhemin, Ott, Sascha, Nübel, Ulrich
• Format: Article
• Language: English
• Subjects: Bacteria - classification; Bacteria - genetics; Bacterial Infections - epidemiology; Bacterial Infections - microbiology; Database Issue; Databases, Genetic; Drug Resistance, Bacterial - genetics; Genome, Bacterial; Genomics - methods; Humans; Internet; Software; User-Computer Interface
• ISSN: 0305-1048; 1362-4962; 1362-4962
• DOI: 10.1093/nar/gkae902

This paper presents an update on the content, accessibility and analytical tools of the EnteroBase platform for web-based pathogen genome analysis. EnteroBase provides manually curated databases of genome sequence data and associated metadata from currently >1.1 million bacterial isolates, more recently including Streptococcus spp. and Mycobacterium tuberculosis, in addition to Salmonella,Escherichia/Shigella,Clostridioides,Vibrio,Helicobacter,YersiniaandMoraxella. We have implemented the genome-based detection of antimicrobial resistance determinants and the new bubble plot graphical tool for visualizing bacterial genomic population structures, based on pre-computed hierarchical clusters. Access to data and analysis tools is provided through an enhanced graphical user interface and a new application programming interface (RESTful API). EnteroBase is now being developed and operated by an international consortium, to accelerate the development of the platform and ensure the longevity of the resources built. EnteroBase can be accessed at https://enterobase.warwick.ac.uk as well as https://enterobase.dsmz.de.