Advances in prenatal surgical management of congenital aqueductal stenosis: A bench to bedside approach

Congenital aqueduct stenosis AS is a significant cause of fetal obstructive hydrocephalus, characterized by the obliteration of the cerebral aqueduct, leading to cerebrospinal fluid (CSF) accumulation in the ventricular system and secondary brain damage and cerebral maldevelopment. This review explo...

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Bibliographic Details
Published in:Seminars in fetal & neonatal medicine 2024-11, Vol.29 (2-3), p.101540, Article 101540
Main Authors: Aydın, Emrah, Duru, Soner, Oria, Marc, Peiro, Jose L.
Format: Article
Language:English
Subjects:
Aqueductal stenosis
Cerebral Aqueduct - diagnostic imaging
Cerebral Aqueduct - surgery
Female
Fetal Diseases - surgery
Fetal hydrocephalus
Humans
Hydrocephalus - diagnostic imaging
Hydrocephalus - surgery
In-utero treatment
Pregnancy
Prenatal Diagnosis - methods
Prenatal Diagnosis - trends
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Summary:Congenital aqueduct stenosis AS is a significant cause of fetal obstructive hydrocephalus, characterized by the obliteration of the cerebral aqueduct, leading to cerebrospinal fluid (CSF) accumulation in the ventricular system and secondary brain damage and cerebral maldevelopment. This review explores the progression from basic science to clinical applications of antenatal surgical interventions for AS, emphasizing historical efforts, current research, and translational studies. Despite advances in prenatal imaging and genetic screening, challenges remain in achieving appropriate fetal candidates, consistent ventricular decompression, and standardized surgical protocols. This review highlights the need for further research and innovation to improve prenatal treatment and outcomes for AS-affected fetuses.
ISSN:1744-165X
1878-0946
1878-0946
DOI:10.1016/j.siny.2024.101540