Genomic insights into fish pathogenic bacteria: A systems biology perspective for sustainable aquaculture

• Published in: Fish & shellfish immunology 2024-11, Vol.154, p.109978, Article 109978
• Main Authors: Sasikumar, R., Saranya, S., Lourdu Lincy, L., Thamanna, L., Chellapandi, P.
• Format: Article
• Language: English
• Subjects: Animals; Aquaculture; Bacteria - genetics; Bacteria - pathogenicity; Bacterial Infections - immunology; Bacterial Infections - prevention & control; Bacterial Infections - veterinary; Bioinformatics; Fish Diseases - immunology; Fish Diseases - microbiology; Fish pathogens; Fishes - immunology; Fishes - microbiology; Genome, Bacterial; Genome-scale models; Genomics; Probiotics - pharmacology; Systems Biology; Virulence
• ISSN: 1050-4648; 1095-9947; 1095-9947
• DOI: 10.1016/j.fsi.2024.109978

Fish diseases significantly challenge global aquaculture, causing substantial financial losses and impacting sustainability, trade, and socioeconomic conditions. Understanding microbial pathogenesis and virulence at the molecular level is crucial for disease prevention in commercial fish. This review provides genomic insights into fish pathogenic bacteria from a systems biology perspective, aiming to promote sustainable aquaculture. It covers the genomic characteristics of various fish pathogens and their industry impact. The review also explores the systems biology of zebrafish, fish bacterial pathogens, and probiotic bacteria, offering insights into fish production, potential vaccines, and therapeutic drugs. Genome-scale metabolic models aid in studying pathogenic bacteria, contributing to disease management and antimicrobial development. Researchers have also investigated probiotic strains to improve aquaculture health. Additionally, the review highlights bioinformatics resources for fish and fish pathogens, which are essential for researchers. Systems biology approaches enhance understanding of bacterial fish pathogens by revealing virulence factors and host interactions. Despite challenges from the adaptability and pathogenicity of bacterial infections, sustainable alternatives are necessary to meet seafood demand. This review underscores the potential of systems biology in understanding fish pathogen biology, improving production, and promoting sustainable aquaculture. •The aquaculture industry is facing challenges due to bacterial diseases and outbreaks.•This review examines the molecular basis of various bacterial infections in fishes.•It provides a summary of bioinformatic resources for fish and fish bacteria pathogens.•It offers valuable systems biology insights into enhancing fish production.