Scalable Copper Sulfide Formulations for Super-Resolution Optoacoustic Brain Imaging in the Second Near-Infrared Window

Optoacoustic imaging offers label-free multi-parametric characterization of cerebrovascular morphology and hemodynamics at depths and spatiotemporal resolution unattainable with optical microscopy. Effective imaging depth can greatly be enhanced by employing photons in the second near-infrared (NIR-...

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Bibliographic Details
Published in:Small methods 2024-10, p.e2400927
Main Authors: Tang, Lin, Nozdriukhin, Daniil, Kalva, Sandeep Kumar, Zhou, Quanyu, Özsoy, Çağla, Lyu, Shuxin, Reiss, Michael, Vidal, Anxo, Torres, Ana, Deán-Ben, Xosé Luís, Razansky, Daniel
Format: Article
Language:English
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Summary:Optoacoustic imaging offers label-free multi-parametric characterization of cerebrovascular morphology and hemodynamics at depths and spatiotemporal resolution unattainable with optical microscopy. Effective imaging depth can greatly be enhanced by employing photons in the second near-infrared (NIR-II) window. However, diminished absorption by hemoglobin along with a lack of suitable contrast agents hinder an efficient application of the technique in this spectral range. Herein, copper sulfide (CuS) micro- and nano-formulations for multi-scale optoacoustic imaging in the NIR-II window are introduced. Dynamic contrast enhancement induced by intravenously administered CuS nanoparticles facilitated visualization of blood perfusion in murine cerebrovascular networks. The individual calcium carbonate microparticles carrying CuS are further shown to generate sufficient responses to enable super-resolution microvascular imaging and blood flow velocity mapping with localization optoacoustic tomography.
ISSN:2366-9608
2366-9608
DOI:10.1002/smtd.202400927