Quiz CORRECT ANSWER TO THE QUIZ. CHECK YOUR DIAGNOSIS Prostatic paraganglia-hyperplasia - a histological mimic of intraprostatic adipose tissue

Prostatic paraganglia (PP) can simulate adenocarcinoma's fused gland pattern, and a differential diagnostic panel is developed. Their differential diagnosis with benign prostatic lesions has been largely unreported. Intraprostatic adipose tissue (IPAT) is seen extremely rarely in prostatic spec...

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Bibliographic Details
Published in:Polish journal of pathology 2024, Vol.75 (3), p.256-258
Main Authors: Stoilova, Mariya, Koleva, Maria, Baltov, Marin, Fakirova, Albena, Dikov, Dorian
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - pathology
Adipose Tissue - pathology
Aged
Diagnosis, Differential
Humans
Immunohistochemistry
Male
Middle Aged
Prostate - pathology
Prostate - surgery
Prostatectomy
Prostatic Hyperplasia - pathology
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
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Summary:Prostatic paraganglia (PP) can simulate adenocarcinoma's fused gland pattern, and a differential diagnostic panel is developed. Their differential diagnosis with benign prostatic lesions has been largely unreported. Intraprostatic adipose tissue (IPAT) is seen extremely rarely in prostatic specimens, but it must be known, to avoid false positive results for extraprostatic fat carcinomatous invasion in needle biopsy specimens.  We present one case from 100 randomly selected radical prostatectomy specimens in which our diagnosis evolved from IPAT to PP-hyperplasia, after additional immunohistochemical investigations. The presence of PP-hyperplasia, with both parenchymal and neurovascular bundle location, and its differential diagnosis with IPAT has not been previously reported.
ISSN:1233-9687
DOI:10.5114/pjp.2024.141368