Potential protection of resveratrol-tempeh against nephrotoxic and hepatotoxic histological damage in mice induced by aluminum

• Published in: Tissue & cell 2024-12, Vol.91, p.102589, Article 102589
• Main Authors: Irnidayanti, Yulia, Wisaksono, Salsabilla Audy Julieta, Darmanto, Win, Narayan, Mahesh, Sarma, Hemen
• Format: Article
• Language: English
• Subjects: Aluminum; Aluminum - toxicity; Animals; Antioxidants - metabolism; Antioxidants - pharmacology; Catalase - metabolism; Hepatotoxic; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Malondialdehyde - metabolism; Mice; Nephrotoxic; Protection; Protective Agents - pharmacology; Resveratrol; Resveratrol - pharmacology; Tempeh
• ISSN: 0040-8166; 1532-3072; 1532-3072
• DOI: 10.1016/j.tice.2024.102589

Aluminum is a widely distributed metal that, while generally safe at low levels, can become toxic when accumulated in the body. Its exposure is daily through various sources, including food, water, and medications. High levels of aluminum have been shown to adversely affect the kidneys and liver, leading to significant organ damage. Resveratrol-tempeh is a safe protective agent against organ damage caused by aluminum. Here, we investigated the impact of resveratrol on liver and kidney toxicity and Al-induced levels of catalase and malondialdehyde. The mice group was the control group, Al-group, Al+REST5-group, and Al+REST10-group. Aluminum and resveratrol were administered intraperitoneally to mice for four weeks, but resveratrol was administered one hour after exposure to aluminum. Mice were killed by cervical dislocation; the liver and kidney were isolated for slide, and the level of an antioxidant enzyme of catalase and oxidant of malondialdehyde was measured. The results showed that administration of aluminum at a dose of 200 mg/kg body weight caused glomerular shrinkage and proximal tubule degeneration in the kidneys. In addition, it also caused liver tissue damage, with hepatocytes undergoing degeneration, sinusoids dilating, and decreased body weight in the mice. Administration of resveratrol-tempeh tended to decrease malondialdehyde levels and increase catalase activity, although the changes were not significant. It seems that resveratrol-tempeh can repair liver and kidney damage and restore them to normal conditions. Conclusion: Aluminum at 200 mg/kg is toxic to mice. Resveratrol-tempeh can be considered a potential candidate to protect kidney and liver damage caused by aluminum chloride toxicity. •Al is toxic to the liver and kidneys.•Resveratrol-Tempeh is a polyphenol produced by tempeh, an Indonesian fermented food.•REST shows a candidate agent for protection against liver and kidney toxicity caused by Al.•Resveratrol-tempeh treatment tends to reduce malondialdehyde levels.•Resveratrol-tempeh treatment tends to reduce catalase levels.