Comparative and combination study of simvastatin alone and in combination with Beta vulgaris in hyperlipidemia patients

Phytomedicine is gaining acceptance as well preference in health care management for various diseases. Drug combinations are mostly used clinically for hyperlipidemia, as single-agent therapy is insufficient. Statins remain the cornerstone of hyperlipidemia. The objective of the present research is...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2024-09, Vol.37 (5), p.1033
Main Authors: Ahmed Shaikh, Nadeem, Khakid, Shamaila, Alam, Mahboob, Hasan, Syed Saud, Rizvi, Fatima, Mobeen, Khadija
Format: Article
Language:English
Subjects:
Adult
Aged
Beets
Care and treatment
Development and progression
Drug synergism
Drug Therapy, Combination
Female
Health aspects
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hyperlipidemia
Hyperlipidemias - blood
Hyperlipidemias - drug therapy
Male
Middle Aged
Patient outcomes
Pharmacology, Experimental
Simvastatin
Simvastatin - administration & dosage
Simvastatin - therapeutic use
Testing
Treatment Outcome
Triglycerides - blood
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Summary:Phytomedicine is gaining acceptance as well preference in health care management for various diseases. Drug combinations are mostly used clinically for hyperlipidemia, as single-agent therapy is insufficient. Statins remain the cornerstone of hyperlipidemia. The objective of the present research is to manage hyperlipidemia with the least amount of medicine effective clinically, thereby limiting its side effects. Study was carried out with 140 registered hyperlipidemia patients, divided into two groups. Group-A received simvastatin 20mg oral daily & Group B received a combination of simvastatin and beta-valgaris capsules twice a day for 90 days. Pre and post treatment values were compared within the groups and between the groups. Group B shows statistically significant decrease (p
ISSN:1011-601X
DOI:10.36721/PJPS.2024.37.5.REG.1033-1041.1