Emerging links between phase separation and transcription factor haploinsufficiency

Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency of transcription factors. Recent studies...

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Bibliographic Details
Published in:Trends in genetics 2024-12, Vol.40 (12), p.998-1000
Main Author: Veitia, Reiner A.
Format: Article
Language:English
Subjects:
Cell Nucleus - genetics
Haploinsufficiency - genetics
Humans
Phase Separation
Transcription Factors - genetics
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Summary:Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency of transcription factors. Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency of transcription factors.
ISSN:0168-9525
DOI:10.1016/j.tig.2024.10.001