Enhanced Mandibular Bone Repair Using Poly Lactic-co-glycolic Acid Combined with Nanohydroxyapatite Scaffold Loaded by Mesenchymal Stromal/Stem Cells and Curcumin in Male Rats

• Published in: ACS biomaterials science & engineering 2024-11, Vol.10 (11), p.7043-7053
• Main Authors: Mokhtarzadegan, Mohamad, Amini, Saba, Iraji, Aida, Kian, Mehdi, Irajie, Cambyz, Sajad Daneshi, Seyyed, Abbaspour, Shekofeh, Zare, Shahrokh, Jamshidzadeh, Akram, Feiz, Ali, Mussin, Nadiar M., Tanideh, Nader, Tamadon, Amin
• Format: Article
• Language: English
• Subjects: Animals; Bone Regeneration - drug effects; Curcumin - chemistry; Curcumin - pharmacology; Durapatite - chemistry; Durapatite - pharmacology; Male; Mandible - drug effects; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - drug effects; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry; Rats; Rats, Wistar; Tissue Engineering and Regenerative Medicine; Tissue Scaffolds - chemistry
• ISSN: 2373-9878; 2373-9878
• DOI: 10.1021/acsbiomaterials.4c00608

This study aimed to investigate the healing effect of a polylactic-co-glycolic acid (PLGA) scaffold containing nanohydroxyapatite (NHA) along with curcumin (CCM), loaded with adipose-derived mesenchymal stem cells (AD-MSCs), on mandibular bone defects. The designed PLGA scaffolds containing NHA were evaluated for their mechanical and structural properties. Forty rats were divided into five groups (n = 8) based on the treatment: Sham, PLGA scaffolds containing NHA, PLGA scaffolds containing NHA + CCM, PLGA scaffolds containing NHA + AD-MSCs, and PLGA scaffolds containing NHA + CCM + AD-MSCs. After 8 weeks’ follow-up, mandible bones were isolated for histomorphometry evaluation. Data were analyzed using SPSS version 21, with p-values