Advances in Injectable Polymeric Biomaterials and Their Contemporary Medical Practices

Injectable biomaterials have been engineered to operate within the human body, offering versatile solutions for minimally invasive therapies and meeting several stringent requirements such as biocompatibility, biodegradability, low viscosity for ease of injection, mechanical strength, rapid gelation...

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Bibliographic Details
Published in:ACS applied bio materials 2024-12, Vol.7 (12), p.8076-8101
Main Authors: Beilharz, Sophia, Debnath, Mithun Kumar, Vinella, Daniele, Shoffstall, Andrew J., Karayilan, Metin
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Drug Delivery Systems
Humans
Injections
Materials Testing
Polymers - chemistry
Regenerative Medicine
Tissue Engineering
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Summary:Injectable biomaterials have been engineered to operate within the human body, offering versatile solutions for minimally invasive therapies and meeting several stringent requirements such as biocompatibility, biodegradability, low viscosity for ease of injection, mechanical strength, rapid gelation postinjection, controlled release of therapeutic agents, hydrophobicity/hydrophilicity balance, stability under physiological conditions, and the ability to be sterilized. Their adaptability and performance in diverse clinical settings make them invaluable for modern medical treatments. This article reviews recent advancements in the design, synthesis, and characterization of injectable polymeric biomaterials, providing insights into their emerging applications. We discuss a broad spectrum of these materials, including natural, synthetic, hybrid, and composite types, that are being applied in targeted drug delivery, cell and protein transport, regenerative medicine, tissue adhesives, injectable implants, bioimaging, diagnostics, and 3D bioprinting. Ultimately, the review highlights the critical role of injectable polymeric biomaterials in shaping the future of medical treatments and improving patient outcomes across a wide range of therapeutic and diagnostic applications.
ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.4c01001