Low Body Mass Index Poses Greater Risk of Primary Open-Angle Glaucoma in African Ancestry Individuals

Investigate the relationship between body mass index (BMI) and primary open-angle glaucoma (POAG) in an African ancestry cohort from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Retrospective, cross-sectional “case-control” comparison study. A total of 6,634 POAAGG study...

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Published in:American journal of ophthalmology 2024-10, Vol.271, p.119-126
Main Authors: Di Rosa, Isabel, Halimitabrizi, Mina, Salowe, Rebecca, Augello, Patrick, Zhu, Di, Chen, Yineng, Sankar, Prithvi, Addis, Victoria, Ying, Gui-Shuang, O'Brien, Joan
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container_title American journal of ophthalmology
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creator Di Rosa, Isabel
Halimitabrizi, Mina
Salowe, Rebecca
Augello, Patrick
Zhu, Di
Chen, Yineng
Sankar, Prithvi
Addis, Victoria
Ying, Gui-Shuang
O'Brien, Joan
description Investigate the relationship between body mass index (BMI) and primary open-angle glaucoma (POAG) in an African ancestry cohort from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Retrospective, cross-sectional “case-control” comparison study. A total of 6,634 POAAGG study subjects were eligible: 2,977 cases and 3,657 controls. Ocular and demographic data were collected from on-site exams, standardized interviews, and electronic medical records. BMI was calculated: weight(kg)/height(m)2, and categorized as low (
doi_str_mv 10.1016/j.ajo.2024.10.023
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Retrospective, cross-sectional “case-control” comparison study. A total of 6,634 POAAGG study subjects were eligible: 2,977 cases and 3,657 controls. Ocular and demographic data were collected from on-site exams, standardized interviews, and electronic medical records. BMI was calculated: weight(kg)/height(m)2, and categorized as low (&lt;18.5), moderate (18.5-24.9), high (25.0-29.9), or very high (≥30). Structural and functional POAG progression were assessed by annual rate of change in retinal nerve fiber layer thickness and visual field mean deviation, respectively, using a linear mixed-effects model. Regression analyses evaluated associations of BMI with POAG status, phenotype, and progression. Lower BMI was associated with increased POAG risk (aOR[95% confidence interval], 1.02 [1.007,1.023] per kg/m2 decrease in BMI, p = .0003). In cases, low BMI was associated with larger cup-to-disc ratio (p = .007) and worse visual acuity (p = .04). Fast functional POAG progressors had a significantly lower mean BMI than slow progressors (25.7 vs. 30.0 kg/m2, p = .04). In this African ancestry cohort, low BMI was associated with increased POAG risk. POAG cases with low BMI were more likely to have larger cup-to-disc ratios, worse visual acuity, and faster functional progression, indicating more severe glaucoma.</description><identifier>ISSN: 0002-9394</identifier><identifier>ISSN: 1879-1891</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2024.10.023</identifier><identifier>PMID: 39471906</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><ispartof>American journal of ophthalmology, 2024-10, Vol.271, p.119-126</ispartof><rights>2024</rights><rights>Copyright © 2024. 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title Low Body Mass Index Poses Greater Risk of Primary Open-Angle Glaucoma in African Ancestry Individuals
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