Advances in triterpene drug discovery

Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2024-11, Vol.45 (11), p.964-968
Main Authors: Goddard, Zoë R, Searcey, Mark, Osbourn, Anne
Format: Article
Language:English
Subjects:
Animals
Biological Products - chemistry
Biological Products - pharmacology
Drug Discovery - methods
Humans
Triterpenes - chemistry
Triterpenes - pharmacology
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Summary:Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.
ISSN:0165-6147
1873-3735
1873-3735
DOI:10.1016/j.tips.2024.10.003