Locoregional control in high-risk neuroblastoma using highly-conformal image-guided radiotherapy, with reduced margins and a boost dose for residual lesions

•RT margins and doses for high-risk neuroblastoma vary across studies.•Highly-conformal IGRT with reduced margins and boost on residue ≥ 1 cm3 was applied.•5-years LRF rate of 7.8 % was excellent and comparable for residue 

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Bibliographic Details
Published in:Radiotherapy and oncology 2025-01, Vol.202, p.110604, Article 110604
Main Authors: Samim, Atia, Littooij, Annemieke S., Peters, Max, de Keizer, Bart, van der Steeg, Alida F.W., Fajardo, Raquel Dávila, Kraal, Kathelijne C.J.M., Dierselhuis, Miranda P., van Eijkelenburg, Natasha K.A., van Grotel, Martine, Polak, Roel, van de Ven, Cornelis P., Wijnen, Marc H.W.A., Seravalli, Enrica, Willemsen-Bosman, Mirjam E., van Noesel, Max M., Tytgat, Godelieve A.M., Janssens, Geert O.
Format: Article
Language:English
Subjects:
Abdominal radiotherapy
Adolescent
Child
Child, Preschool
Female
High-risk neuroblastoma
Highly conformal radiotherapy
Humans
Image-guided radiotherapy
Infant
Locoregional failure
Male
Neoplasm, Residual - radiotherapy
Neuroblastoma - diagnostic imaging
Neuroblastoma - pathology
Neuroblastoma - radiotherapy
Pattern of failure
Radiotherapy boost
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Conformal - methods
Radiotherapy, Image-Guided - methods
Radiotherapy, Intensity-Modulated - methods
Residue
Retrospective Studies
Tertiary hospital
Citations: Items that this one cites
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Description
Summary:•RT margins and doses for high-risk neuroblastoma vary across studies.•Highly-conformal IGRT with reduced margins and boost on residue ≥ 1 cm3 was applied.•5-years LRF rate of 7.8 % was excellent and comparable for residue 
ISSN:0167-8140
1879-0887
1879-0887
DOI:10.1016/j.radonc.2024.110604