Longitudinal analysis of astrocyte-derived protein levels in the blood of drug-naive and relapsed patients with schizophrenia

The potential influence of astrocytes on neuronal circuitry and psychotic symptoms in schizophrenia have recently been highlighted. Human postmortem studies have observed reduced astrocyte numbers in schizophrenia, but whether this pathology is present at disease onset or accumulates progressively w...

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Published in:Journal of psychiatric research 2024-12, Vol.180, p.301-306
Main Authors: Mukherjee, Kaushiki, Guest, Paul C., Schiltz, Kolja, Meyer-Lotz, Gabriela, Dobrowolny, Henrik, Borucki, Katrin, Bernstein, Hans-Gert, Nickl-Jockschat, Thomas, Relja, Borna, Steiner, Johann
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - pharmacology
Astrocyte pathology
Astrocytes - metabolism
Astrocytes - pathology
Blood biomarkers
FABP7
Fatty Acid-Binding Protein 7 - blood
Fatty Acid-Binding Proteins - blood
Female
GFAP
Glial Fibrillary Acidic Protein - blood
Humans
Longitudinal Studies
Male
Middle Aged
Recurrence
Schizophrenia
Schizophrenia - blood
Schizophrenia - drug therapy
Tumor Suppressor Proteins
Young Adult
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Summary:The potential influence of astrocytes on neuronal circuitry and psychotic symptoms in schizophrenia have recently been highlighted. Human postmortem studies have observed reduced astrocyte numbers in schizophrenia, but whether this pathology is present at disease onset or accumulates progressively with further psychotic episodes remains unclear. Therefore, we analysed serum levels of the astrocyte-derived proteins glial fibrillary acidic protein (GFAP) and fatty acid-binding protein 7 (FABP7) in acutely ill first-episode (n = 60) and relapsed (n = 34) schizophrenia patients compared to 94 matched controls. Measurements were taken before and 6 weeks after antipsychotic treatment. We found significantly lower levels of GFAP (p 
ISSN:0022-3956
1879-1379
1879-1379
DOI:10.1016/j.jpsychires.2024.10.007