Time to positivity of Coagulase Negative Staphylococcus In Neonatal Blood Cultures as an adjunct tool to help discriminate between sepsis and contamination

Objective To assess the usefulness of time to positivity (TTP) to distinguish between sepsis and contamination in coagulase-negative staphylococci (CoNS) isolates. Study design Unicentric retrospective observational. Medical records of 168 patients with suspected sepsis and positive blood culture fo...

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Bibliographic Details
Published in:Journal of perinatology 2025, Vol.45 (1), p.111-115
Main Authors: Carbonell-Sahuquillo, Silvia, Olea, Beatriz, Pérez-Suárez, Raquel, Giménez, Estela, Colomina, Javier, Navarro, David, Estañ-Capell, Javier
Format: Article
Language:English
Subjects:
692/53/2421
692/699/255/1318
Blood
Blood Culture
Blood tests
Bradycardia
Coagulase
Contamination
Diagnosis, Differential
Diagnostic tests
Female
Gestational Age
Humans
Infant, Newborn
Lethargy
Logistic Models
Male
Medical records
Medicine
Medicine & Public Health
Neonatal Sepsis - blood
Neonatal Sepsis - diagnosis
Neonatal Sepsis - microbiology
Neonates
Newborn babies
Patients
Pediatric Surgery
Pediatrics
Regression analysis
Retrospective Studies
Risk Factors
Sepsis
Sepsis - blood
Sepsis - diagnosis
Sepsis - microbiology
Signs and symptoms
Staphylococcal Infections - diagnosis
Staphylococcus - isolation & purification
Staphylococcus infections
Tachycardia
Time Factors
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Summary:Objective To assess the usefulness of time to positivity (TTP) to distinguish between sepsis and contamination in coagulase-negative staphylococci (CoNS) isolates. Study design Unicentric retrospective observational. Medical records of 168 patients with suspected sepsis and positive blood culture for CoNS were reviewed. Patients were subdivided into sepsis (29%) and probable contamination (71%). Logistic regression analyses were performed to evaluate different risk factors and clinical signs and symptoms associated with sepsis. Results TTP cut-off value that best discriminated sepsis from contamination was found to be 18 h. Regression analysis revealed that TTP ≤ 18 h, gestational age ≤32 weeks, taquycardia/bradycardia and hypoactivity/lethargy were independent predictors of sepsis. Conclusion TTP is useful in distinguishing sepsis from contamination, especially in neonates with lower gestational age (
ISSN:0743-8346
1476-5543
1476-5543
DOI:10.1038/s41372-024-02158-0