Association between fluctuations in blood cholesterol levels and the risk of suicide death in the general population

Suicide is a pressing global public health issue. While recent studies have explored the association between serum cholesterol levels and suicide risk, the association between cholesterol variability and suicide risk is not well characterized. This was a nationwide population-based cohort study usin...

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Bibliographic Details
Published in:Journal of psychosomatic research 2024-12, Vol.187, p.111956, Article 111956
Main Authors: Jeong, Chaiho, Jung, Jin-Hyung, Oh, Dae Jong, Han, Kyungdo, Kim, Mee Kyoung
Format: Article
Language:English
Subjects:
Cholesterol
Suicide
Variability
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Summary:Suicide is a pressing global public health issue. While recent studies have explored the association between serum cholesterol levels and suicide risk, the association between cholesterol variability and suicide risk is not well characterized. This was a nationwide population-based cohort study using data from the Korean National Health Insurance Service database. A total of 1,983,701 patients with at least three measurements of TC between 2004 and 2009 were included. Participants were followed until death by suicide or the study's end in December 2021. Participants were categorized based on baseline TC or TC variability. TC variability was assessed using coefficient of variation (CV), variability independent of the mean (VIM), and average successive variability (ASV). Over a median follow-up of 11 years, 5883 (0.3 %) patients died by suicide. Compared to subjects with TC
ISSN:0022-3999
1879-1360
1879-1360
DOI:10.1016/j.jpsychores.2024.111956