Adulthood dietary and lifestyle patterns and risk of breast cancer: Global Cancer Update Programme (CUP Global) systematic literature review

• Published in: The American journal of clinical nutrition 2024-10
• Main Authors: Konieczna, Jadwiga, Chaplin, Alice, Paz-Graniel, Indira, Croker, Helen, Becerra-Tomás, Nerea, Markozannes, Georgios, Tsilidis, Konstantinos K, Dossus, Laure, Gonzalez-Gil, Esther M, Park, Yikyung, Krebs, John, Weijenberg, Matty P, Baskin, Monica L, Copson, Ellen, Lewis, Sarah J, Seidell, Jacob C, Chowdhury, Rajiv, Hill, Lynette, Chan, Doris SM, Romaguera, Dora
• Format: Article
• Language: English
• Subjects: a posteriori dietary patterns; a priori dietary patterns; breast cancer incidence; dietary and lifestyle patterns; evidence grading; hybrid dietary patterns; systematic review
• ISSN: 0002-9165; 1938-3207; 1938-3207
• DOI: 10.1016/j.ajcnut.2024.10.003

An increasing number of studies in recent years investigate various dietary and lifestyle patterns and associated breast cancer (BC) risk. This study aimed to comprehensively synthesize and grade the evidence on dietary and lifestyle patterns and BC risk. Databases were systematically searched up to 31 March, 2022, for evidence from randomised controlled trials and prospective cohort studies on adherence to a dietary pattern alone or in combination with lifestyle behaviors and incidence of or mortality from primary BC in adult females. Findings in all, premenopausal, and postmenopausal females were descriptively synthesized instead of meta-analyzed due to patterns heterogeneity. An independent Global Cancer Update Programme Expert Panel graded the strength of the evidence. A total of 84 publications were included. Results for patterns reflecting both a healthy diet and lifestyle were more consistent than for patterns that included diet only. There was strong-probable evidence that a priori World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and American Cancer Society (ACS) dietary and lifestyle scores may reduce BC risk in all and postmenopausal females, whereas in premenopausal females, less evidence was found contributing to limited-suggestive grade. There was also a limited-suggestive evidence that adherence to the Healthy Lifestyle Index and other diet and lifestyle scores may reduce BC risk in postmenopausal females; a posteriori Western/Meat/Alcohol dietary patterns may increase BC risk in postmenopausal females; and Prudent/Vegetarian/Mediterranean dietary patterns may reduce BC risk in all females. For the remaining patterns, evidence was graded as limited-no conclusions. Advice to adopt combined aspects of a healthy diet and lifestyle according to WCRF/AICR and ACS scores, encouraging a healthy weight, physical activity, alcohol and smoking avoidance, and a healthy diet rich in fruits, vegetables, (whole)grains and cereals and discouraging red and processed meat, can be proposed to females to lower BC risk. This review was registered at PROSPERO as ID CRD42021270129 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021270129) on 28 August, 2021, and further updated on 4 May, 2022, in order to extend the search period.