Lacosamide for the Treatment of Seizures in Neonates and Infants: A Retrospective Assessment of Efficacy and Tolerability

A retrospective study was conducted to assess the safety and efficacy of lacosamide in children less than 24 months of age. Patients were included if they were 50% reduction in seizure burden. In addition, patients’ charts were reviewed until 24 months of age to assess for any adverse effects attrib...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric neurology 2023-12, Vol.149, p.176-181
Main Authors: Shoaib, Abdullah B., Machie, Michelle, Thomas, Jennifer M., Dolce, Alison
Format: Article
Language:English
Subjects:
infants
lacosamide
neonatal
neonates
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A retrospective study was conducted to assess the safety and efficacy of lacosamide in children less than 24 months of age. Patients were included if they were 50% reduction in seizure burden. In addition, patients’ charts were reviewed until 24 months of age to assess for any adverse effects attributed to maintenance lacosamide therapy, with adverse effects noted in three patients (abnormal movements in two patients, worsened seizures in one patient). This study is among the largest retrospective chart reviews investigating use of lacosamide in children, and the first investigating the efficacy of lacosamide in children
ISSN:0887-8994
1873-5150
1873-5150
DOI:10.1016/j.pediatrneurol.2023.09.021