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To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance
Malaria remains a global health challenge with significant mortality and morbidity annually, with resistant parasite strains complicating treatment efforts. There is an acute need for novel antimalarial drugs that can put a stop to the future public health crisis caused by the multi-drug resistance...
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Published in: | Journal of parasitic diseases 2024-12, Vol.48 (4), p.671-722 |
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creator | Biswas, Pratyusa Roy, Rini Ghosh, Kuldip Nath, Debjani Samadder, Asmita Nandi, Sisir |
description | Malaria remains a global health challenge with significant mortality and morbidity annually, with resistant parasite strains complicating treatment efforts. There is an acute need for novel antimalarial drugs that can put a stop to the future public health crisis caused by the multi-drug resistance strains of the
Plasmodium
parasite
.
However, the discovery of these new components is very challenging in the context of the generation of multi-drug resistance properties of malaria. The novel drugs also need to have several properties involving enhanced therapeutic prospects, successful treatment capabilities, and novel mechanisms of action that will forestall the resistance. To successfully achieve this aim researchers are trying to focus on exploring promising malaria targets. Various approaches have been made for the development of drugs for malaria including the remodelling of existing drugs and the development of novel inhibitors which acts on new targets. Advancement in the study provides more information on the biology of parasites and the new targets which help in the development of novel drugs. The present review focuses on the study of novel targets of malaria parasites and subsequent inhibitors of those particular targets. Some of these targets include malarial protease, various transporter proteins, enzymes involved in the synthesis of DNA, and nucleic acids like dihydroorotate dehydrogenase, dihydrofolate reductase, apicoplast and dihydropteroate synthase. Other potential targets are also included in this review such as isoprenoid biosynthesis, farnesyl transferase of parasite,
P. falciparum
translational elongation factor 2, and phosphatidyl inositol 4 kinase. These promising targets have also been summed up along with their corresponding inhibitors for combating multi-drug resistance malaria. |
doi_str_mv | 10.1007/s12639-024-01687-x |
format | article |
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Plasmodium
parasite
.
However, the discovery of these new components is very challenging in the context of the generation of multi-drug resistance properties of malaria. The novel drugs also need to have several properties involving enhanced therapeutic prospects, successful treatment capabilities, and novel mechanisms of action that will forestall the resistance. To successfully achieve this aim researchers are trying to focus on exploring promising malaria targets. Various approaches have been made for the development of drugs for malaria including the remodelling of existing drugs and the development of novel inhibitors which acts on new targets. Advancement in the study provides more information on the biology of parasites and the new targets which help in the development of novel drugs. The present review focuses on the study of novel targets of malaria parasites and subsequent inhibitors of those particular targets. Some of these targets include malarial protease, various transporter proteins, enzymes involved in the synthesis of DNA, and nucleic acids like dihydroorotate dehydrogenase, dihydrofolate reductase, apicoplast and dihydropteroate synthase. Other potential targets are also included in this review such as isoprenoid biosynthesis, farnesyl transferase of parasite,
P. falciparum
translational elongation factor 2, and phosphatidyl inositol 4 kinase. These promising targets have also been summed up along with their corresponding inhibitors for combating multi-drug resistance malaria.</description><identifier>ISSN: 0971-7196</identifier><identifier>EISSN: 0975-0703</identifier><identifier>DOI: 10.1007/s12639-024-01687-x</identifier><identifier>PMID: 39493470</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Antimalarial agents ; Antiparasitic agents ; Blood parasites ; Dihydrofolate reductase ; Dihydroorotate dehydrogenase ; Dihydropteroate synthase ; DNA biosynthesis ; Drug development ; Drug discovery ; Drug resistance ; Health Promotion and Disease Prevention ; Infectious Diseases ; Inositol ; Kinases ; Malaria ; Medicine ; Medicine & Public Health ; Morbidity ; Multidrug resistance ; Parasite resistance ; Parasites ; Plasmodium ; Protein transport ; Proteinase inhibitors ; Public health ; Review Article ; Translation elongation</subject><ispartof>Journal of parasitic diseases, 2024-12, Vol.48 (4), p.671-722</ispartof><rights>Indian Society for Parasitology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c171x-54c6bf0718be1c0c53623b8b8b4ee8476001e890fbf22a0b7062dafa386057bd3</cites><orcidid>0000-0002-9960-6584</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39493470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biswas, Pratyusa</creatorcontrib><creatorcontrib>Roy, Rini</creatorcontrib><creatorcontrib>Ghosh, Kuldip</creatorcontrib><creatorcontrib>Nath, Debjani</creatorcontrib><creatorcontrib>Samadder, Asmita</creatorcontrib><creatorcontrib>Nandi, Sisir</creatorcontrib><title>To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance</title><title>Journal of parasitic diseases</title><addtitle>J Parasit Dis</addtitle><addtitle>J Parasit Dis</addtitle><description>Malaria remains a global health challenge with significant mortality and morbidity annually, with resistant parasite strains complicating treatment efforts. There is an acute need for novel antimalarial drugs that can put a stop to the future public health crisis caused by the multi-drug resistance strains of the
Plasmodium
parasite
.
However, the discovery of these new components is very challenging in the context of the generation of multi-drug resistance properties of malaria. The novel drugs also need to have several properties involving enhanced therapeutic prospects, successful treatment capabilities, and novel mechanisms of action that will forestall the resistance. To successfully achieve this aim researchers are trying to focus on exploring promising malaria targets. Various approaches have been made for the development of drugs for malaria including the remodelling of existing drugs and the development of novel inhibitors which acts on new targets. Advancement in the study provides more information on the biology of parasites and the new targets which help in the development of novel drugs. The present review focuses on the study of novel targets of malaria parasites and subsequent inhibitors of those particular targets. Some of these targets include malarial protease, various transporter proteins, enzymes involved in the synthesis of DNA, and nucleic acids like dihydroorotate dehydrogenase, dihydrofolate reductase, apicoplast and dihydropteroate synthase. Other potential targets are also included in this review such as isoprenoid biosynthesis, farnesyl transferase of parasite,
P. falciparum
translational elongation factor 2, and phosphatidyl inositol 4 kinase. These promising targets have also been summed up along with their corresponding inhibitors for combating multi-drug resistance malaria.</description><subject>Antimalarial agents</subject><subject>Antiparasitic agents</subject><subject>Blood parasites</subject><subject>Dihydrofolate reductase</subject><subject>Dihydroorotate dehydrogenase</subject><subject>Dihydropteroate synthase</subject><subject>DNA biosynthesis</subject><subject>Drug development</subject><subject>Drug discovery</subject><subject>Drug resistance</subject><subject>Health Promotion and Disease Prevention</subject><subject>Infectious Diseases</subject><subject>Inositol</subject><subject>Kinases</subject><subject>Malaria</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Multidrug resistance</subject><subject>Parasite resistance</subject><subject>Parasites</subject><subject>Plasmodium</subject><subject>Protein transport</subject><subject>Proteinase inhibitors</subject><subject>Public health</subject><subject>Review Article</subject><subject>Translation elongation</subject><issn>0971-7196</issn><issn>0975-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU9rGzEQxUVIyR8nXyCHIsill21G0nqlPRbTNoFAc3DPQtqdtRV2V7akJc63r2wnLfQQdBih-c0bPR4hNwy-MgB5FxmvRF0ALwtglZLF7oRcQC3nBUgQp4c7KySrq3NyGeMzwDy_qzNyLuqyFqWEC7JderqdMCY64gtNJqwwReo7-tSbOPjWTQPdmGCiS0jN2NK0RhfoxicckzM9dePaWZd8iDR52vjBmpTB5AbTm7An2jCtaMDoYjJjg1fkU2f6iNdvdUZ-__i-XNwXj79-Piy-PRYNk2xXzMumsh1IpiyyBpq5qLiwKp8SUZWyAmCoauhsx7kBK6HiremMUFW2aVsxI1-OupvgDw714GKDfW9G9FPUgnGhQNWSZ_T2P_TZT2HMvztQUNYgRab4kWqCjzFgpzchuwyvmoHeB6KPgegciD4Eond56POb9GQHbP-OvCeQAXEEYm6NKwz_dn8g-wfWAJgW</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Biswas, Pratyusa</creator><creator>Roy, Rini</creator><creator>Ghosh, Kuldip</creator><creator>Nath, Debjani</creator><creator>Samadder, Asmita</creator><creator>Nandi, Sisir</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9960-6584</orcidid></search><sort><creationdate>202412</creationdate><title>To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance</title><author>Biswas, Pratyusa ; Roy, Rini ; Ghosh, Kuldip ; Nath, Debjani ; Samadder, Asmita ; Nandi, Sisir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c171x-54c6bf0718be1c0c53623b8b8b4ee8476001e890fbf22a0b7062dafa386057bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antimalarial agents</topic><topic>Antiparasitic agents</topic><topic>Blood parasites</topic><topic>Dihydrofolate reductase</topic><topic>Dihydroorotate dehydrogenase</topic><topic>Dihydropteroate synthase</topic><topic>DNA biosynthesis</topic><topic>Drug development</topic><topic>Drug discovery</topic><topic>Drug resistance</topic><topic>Health Promotion and Disease Prevention</topic><topic>Infectious Diseases</topic><topic>Inositol</topic><topic>Kinases</topic><topic>Malaria</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Multidrug resistance</topic><topic>Parasite resistance</topic><topic>Parasites</topic><topic>Plasmodium</topic><topic>Protein transport</topic><topic>Proteinase inhibitors</topic><topic>Public health</topic><topic>Review Article</topic><topic>Translation elongation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biswas, Pratyusa</creatorcontrib><creatorcontrib>Roy, Rini</creatorcontrib><creatorcontrib>Ghosh, Kuldip</creatorcontrib><creatorcontrib>Nath, Debjani</creatorcontrib><creatorcontrib>Samadder, Asmita</creatorcontrib><creatorcontrib>Nandi, Sisir</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of parasitic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biswas, Pratyusa</au><au>Roy, Rini</au><au>Ghosh, Kuldip</au><au>Nath, Debjani</au><au>Samadder, Asmita</au><au>Nandi, Sisir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance</atitle><jtitle>Journal of parasitic diseases</jtitle><stitle>J Parasit Dis</stitle><addtitle>J Parasit Dis</addtitle><date>2024-12</date><risdate>2024</risdate><volume>48</volume><issue>4</issue><spage>671</spage><epage>722</epage><pages>671-722</pages><issn>0971-7196</issn><eissn>0975-0703</eissn><abstract>Malaria remains a global health challenge with significant mortality and morbidity annually, with resistant parasite strains complicating treatment efforts. There is an acute need for novel antimalarial drugs that can put a stop to the future public health crisis caused by the multi-drug resistance strains of the
Plasmodium
parasite
.
However, the discovery of these new components is very challenging in the context of the generation of multi-drug resistance properties of malaria. The novel drugs also need to have several properties involving enhanced therapeutic prospects, successful treatment capabilities, and novel mechanisms of action that will forestall the resistance. To successfully achieve this aim researchers are trying to focus on exploring promising malaria targets. Various approaches have been made for the development of drugs for malaria including the remodelling of existing drugs and the development of novel inhibitors which acts on new targets. Advancement in the study provides more information on the biology of parasites and the new targets which help in the development of novel drugs. The present review focuses on the study of novel targets of malaria parasites and subsequent inhibitors of those particular targets. Some of these targets include malarial protease, various transporter proteins, enzymes involved in the synthesis of DNA, and nucleic acids like dihydroorotate dehydrogenase, dihydrofolate reductase, apicoplast and dihydropteroate synthase. Other potential targets are also included in this review such as isoprenoid biosynthesis, farnesyl transferase of parasite,
P. falciparum
translational elongation factor 2, and phosphatidyl inositol 4 kinase. These promising targets have also been summed up along with their corresponding inhibitors for combating multi-drug resistance malaria.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>39493470</pmid><doi>10.1007/s12639-024-01687-x</doi><tpages>52</tpages><orcidid>https://orcid.org/0000-0002-9960-6584</orcidid></addata></record> |
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subjects | Antimalarial agents Antiparasitic agents Blood parasites Dihydrofolate reductase Dihydroorotate dehydrogenase Dihydropteroate synthase DNA biosynthesis Drug development Drug discovery Drug resistance Health Promotion and Disease Prevention Infectious Diseases Inositol Kinases Malaria Medicine Medicine & Public Health Morbidity Multidrug resistance Parasite resistance Parasites Plasmodium Protein transport Proteinase inhibitors Public health Review Article Translation elongation |
title | To quest new targets of Plasmodium parasite and their potential inhibitors to combat antimalarial drug resistance |
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