Clues from an ionic cocrystal structure: from catalysis to mechanochemistry

A crystal structure is no longer conceived as a static entity; rather, it often mirrors crystallization pathways, linking crystal structures with a solution scenario. In this study, taking a clue from a previously reported ionic cocrystal structure, an in situ acetic acid-based catalytic protocol is...

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Bibliographic Details
Published in:RSC advances 2024-10, Vol.14 (47), p.34843-34847
Main Authors: Sar, Bandana, Ahsan, Mollah Rohan, Mukherjee, Arijit
Format: Article
Language:English
Subjects:
Acetic acid
Acylation
Amines
Catalysis
Chemistry
Crystal structure
Crystallization
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Summary:A crystal structure is no longer conceived as a static entity; rather, it often mirrors crystallization pathways, linking crystal structures with a solution scenario. In this study, taking a clue from a previously reported ionic cocrystal structure, an in situ acetic acid-based catalytic protocol is developed for the N -acylation of amines using ester sources. In addition to better catalytic efficiency, this in situ approach was extended further to a mechanochemistry protocol in the context of a multicomponent reaction. This points towards a broader applicability of crystal structures that goes beyond the domain of structural chemistry and delves into catalysis and mechanosynthesis. A crystal structure is no longer conceived as a static entity; rather, it often mirrors crystallization pathways, linking crystal structures with a solution scenario.
ISSN:2046-2069
2046-2069
DOI:10.1039/d4ra05652c