Synthesis of benzofquinazoline-1,3(2H,4H)-diones

We report the synthesis of polycyclic uracil derivatives. The method is based on palladium-catalysed Sonogashira-Hagihara and Suzuki-Miyaura cross-coupling reactions followed by Brønsted acid-mediated cycloisomerisation. The developed methodology tolerates various functional groups and leads to mode...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2024-01, Vol.20, p.2708
Main Authors: de Abreu, Ruben Manuel Figueira, Ehlers, Peter, Langer, Peter
Format: Article
Language:English
Online Access:Get full text
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Summary:We report the synthesis of polycyclic uracil derivatives. The method is based on palladium-catalysed Sonogashira-Hagihara and Suzuki-Miyaura cross-coupling reactions followed by Brønsted acid-mediated cycloisomerisation. The developed methodology tolerates various functional groups and leads to moderate up to quantitative yields of the final products. The impact of different functional groups on the optical properties was studied by UV-vis and fluorescence spectroscopy.We report the synthesis of polycyclic uracil derivatives. The method is based on palladium-catalysed Sonogashira-Hagihara and Suzuki-Miyaura cross-coupling reactions followed by Brønsted acid-mediated cycloisomerisation. The developed methodology tolerates various functional groups and leads to moderate up to quantitative yields of the final products. The impact of different functional groups on the optical properties was studied by UV-vis and fluorescence spectroscopy.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.20.228