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Effects of vaccination on antibody level and duration of viral shedding in Omicron patients
We compared the clinical characteristics of vaccinated and non-vaccinated Omicron patients in order to provide a reference for the clinical diagnosis and treatment of coronavirus disease 2019 (COVID-19). This study included 360 patients diagnosed with COVID-19. The serum immunoglobulin G (IgG) and s...
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| Published in: | Journal of infection in developing countries 2024-09, Vol.18 (9.1), p.S184-S190 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| container_end_page | S190 |
| container_issue | 9.1 |
| container_start_page | S184 |
| container_title | Journal of infection in developing countries |
| container_volume | 18 |
| creator | Wan, Zhen Han, Jing Wang, Deyin Li, Yonghui Zhai, Weixiang Zhao, Weikang Zhang, Xiaodong Xie, Yi |
| description | We compared the clinical characteristics of vaccinated and non-vaccinated Omicron patients in order to provide a reference for the clinical diagnosis and treatment of coronavirus disease 2019 (COVID-19).
This study included 360 patients diagnosed with COVID-19. The serum immunoglobulin G (IgG) and serum immunoglobulin M (IgM) antibody levels of the patients and the duration of virus shedding were analyzed according to age, gender, vaccine dose, and the time from the most recent vaccination to the onset of Omicron infection.
Age (OR = 0.974), days from last vaccination to onset ≤ 180 days (OR = 4.409), and booster dose of the vaccine (OR = 4.999) were protective factors associated with patients who were IgG antibody positive. The duration of virus shedding in IgG -antibody-positive patients was 9 (8-11) days; and this was significantly lower than that in IgG-antibody-negative patients, who had virus shedding duration of 10 (8-12) days (p < 0.05).
Booster immunizations could increase IgG-antibody in patients who have already been infected with the Omicron variant and enhance immune protection. In addition, COVID-19 vaccination may shorten the duration of virus shedding. |
| doi_str_mv | 10.3855/jidc.19160 |
| format | article |
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This study included 360 patients diagnosed with COVID-19. The serum immunoglobulin G (IgG) and serum immunoglobulin M (IgM) antibody levels of the patients and the duration of virus shedding were analyzed according to age, gender, vaccine dose, and the time from the most recent vaccination to the onset of Omicron infection.
Age (OR = 0.974), days from last vaccination to onset ≤ 180 days (OR = 4.409), and booster dose of the vaccine (OR = 4.999) were protective factors associated with patients who were IgG antibody positive. The duration of virus shedding in IgG -antibody-positive patients was 9 (8-11) days; and this was significantly lower than that in IgG-antibody-negative patients, who had virus shedding duration of 10 (8-12) days (p < 0.05).
Booster immunizations could increase IgG-antibody in patients who have already been infected with the Omicron variant and enhance immune protection. In addition, COVID-19 vaccination may shorten the duration of virus shedding.</description><identifier>ISSN: 1972-2680</identifier><identifier>ISSN: 2036-6590</identifier><identifier>EISSN: 1972-2680</identifier><identifier>DOI: 10.3855/jidc.19160</identifier><identifier>PMID: 39499763</identifier><language>eng</language><publisher>Italy: Journal of Infection in Developing Countries</publisher><subject>Adolescent ; Adult ; Aged ; Antibodies ; Antibodies, Viral - blood ; Coronaviruses ; COVID-19 - immunology ; COVID-19 - prevention & control ; COVID-19 vaccines ; COVID-19 Vaccines - administration & dosage ; COVID-19 Vaccines - immunology ; Female ; Humans ; Immunization ; Immunization, Secondary ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Immunoglobulins ; Male ; Middle Aged ; SARS-CoV-2 - immunology ; Time Factors ; Vaccination ; Virus Shedding ; Young Adult</subject><ispartof>Journal of infection in developing countries, 2024-09, Vol.18 (9.1), p.S184-S190</ispartof><rights>Copyright (c) 2024 Zhen Wan, Jing Han, Deyin Wang, Yonghui Li, Weixiang Zhai, Weikang Zhao, Xiaodong Zhang, Yi Xie.</rights><rights>2024. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-5672-3158 ; 0000-0001-6877-2996 ; 0000-0003-2360-1290</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3131344532?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25732,27903,27904,36991,36992,38495,43874,44569</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39499763$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan, Zhen</creatorcontrib><creatorcontrib>Han, Jing</creatorcontrib><creatorcontrib>Wang, Deyin</creatorcontrib><creatorcontrib>Li, Yonghui</creatorcontrib><creatorcontrib>Zhai, Weixiang</creatorcontrib><creatorcontrib>Zhao, Weikang</creatorcontrib><creatorcontrib>Zhang, Xiaodong</creatorcontrib><creatorcontrib>Xie, Yi</creatorcontrib><title>Effects of vaccination on antibody level and duration of viral shedding in Omicron patients</title><title>Journal of infection in developing countries</title><addtitle>J Infect Dev Ctries</addtitle><description>We compared the clinical characteristics of vaccinated and non-vaccinated Omicron patients in order to provide a reference for the clinical diagnosis and treatment of coronavirus disease 2019 (COVID-19).
This study included 360 patients diagnosed with COVID-19. The serum immunoglobulin G (IgG) and serum immunoglobulin M (IgM) antibody levels of the patients and the duration of virus shedding were analyzed according to age, gender, vaccine dose, and the time from the most recent vaccination to the onset of Omicron infection.
Age (OR = 0.974), days from last vaccination to onset ≤ 180 days (OR = 4.409), and booster dose of the vaccine (OR = 4.999) were protective factors associated with patients who were IgG antibody positive. The duration of virus shedding in IgG -antibody-positive patients was 9 (8-11) days; and this was significantly lower than that in IgG-antibody-negative patients, who had virus shedding duration of 10 (8-12) days (p < 0.05).
Booster immunizations could increase IgG-antibody in patients who have already been infected with the Omicron variant and enhance immune protection. 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This study included 360 patients diagnosed with COVID-19. The serum immunoglobulin G (IgG) and serum immunoglobulin M (IgM) antibody levels of the patients and the duration of virus shedding were analyzed according to age, gender, vaccine dose, and the time from the most recent vaccination to the onset of Omicron infection.
Age (OR = 0.974), days from last vaccination to onset ≤ 180 days (OR = 4.409), and booster dose of the vaccine (OR = 4.999) were protective factors associated with patients who were IgG antibody positive. The duration of virus shedding in IgG -antibody-positive patients was 9 (8-11) days; and this was significantly lower than that in IgG-antibody-negative patients, who had virus shedding duration of 10 (8-12) days (p < 0.05).
Booster immunizations could increase IgG-antibody in patients who have already been infected with the Omicron variant and enhance immune protection. In addition, COVID-19 vaccination may shorten the duration of virus shedding.</abstract><cop>Italy</cop><pub>Journal of Infection in Developing Countries</pub><pmid>39499763</pmid><doi>10.3855/jidc.19160</doi><orcidid>https://orcid.org/0000-0002-5672-3158</orcidid><orcidid>https://orcid.org/0000-0001-6877-2996</orcidid><orcidid>https://orcid.org/0000-0003-2360-1290</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1972-2680 |
| ispartof | Journal of infection in developing countries, 2024-09, Vol.18 (9.1), p.S184-S190 |
| issn | 1972-2680 2036-6590 1972-2680 |
| language | eng |
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| source | Publicly Available Content (ProQuest); Coronavirus Research Database |
| subjects | Adolescent Adult Aged Antibodies Antibodies, Viral - blood Coronaviruses COVID-19 - immunology COVID-19 - prevention & control COVID-19 vaccines COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Female Humans Immunization Immunization, Secondary Immunoglobulin G - blood Immunoglobulin M - blood Immunoglobulins Male Middle Aged SARS-CoV-2 - immunology Time Factors Vaccination Virus Shedding Young Adult |
| title | Effects of vaccination on antibody level and duration of viral shedding in Omicron patients |
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